Type II topoisomerase - Wikipedia
Type II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP , unlike Type I topoisomerase .
Diversity and Functions of Type II Topoisomerases - PMC
Here, we review the catalytic cycles, evolution, diversity, and functional roles of type II topoisomerases in organisms from all domains of life, as well as viruses and other mobile genetic elements. Keywords: topoisomerases, supercoiling, decatenation, transcription, replication, DNA segregation, spatial chromosome organization
DNA topoisomerase II and its growing repertoire of …
2009年4月20日 · There are two broad classes of type II topoisomerases: type IIA topoisomerases, which include prokaryotic DNA gyrase, prokaryotic topoisomerase IV and eukaryotic topoisomerase II (TOP2), and...
Targeting DNA topoisomerase II in cancer chemotherapy
2009年4月20日 · The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent studies lead to refined targeting of...
Targeting DNA topoisomerase II in cancer chemotherapy
This mode of inhibition occurs for most currently used Top2 targeting agents including anthracyclines and epipodophyllotoxins, as well as for agents that target prokaryotic type II topoisomerases. These agents prevent enzyme turnover, and therefore greatly inhibit the enzyme catalytic activity, however, the clearest effect is the generation of ...
Topoisomerase - Wikipedia
Type II topoisomerases catalyze changes in DNA topology via transient double-stranded breaks in DNA. Reactions occur on double-stranded DNA substrates and proceed via a strand-passage mechanism (Fig. 5). The range of reactions include DNA relaxation, DNA supercoiling, unknotting, and decatenation.
Structural insights into the DNA topoisomerase II of the
2024年5月30日 · Topoisomerase II (Topo II) represents conserved enzymes pivotal in regulating the topological conformation of DNA molecules during a range of essential physiological processes, encompassing DNA ...
Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II
2024年10月30日 · Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication and transcription. In cells, type II topoisomerases are particularly ...
DNA topoisomerases: structure, function, and mechanism
DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA.
Topoisomerase – Definition, Types, Structure, and Functions
2023年11月25日 · Type II topoisomerases are homodimeric or heterotetrameric enzymes that introduce double-stranded breaks in the DNA molecule. It is an ATP-dependent enzyme that changes the linking number by 1. The process starts when type II enzymes attach to the double-stranded DNA substrates.