Developmental programming of CpG island methylation profiles …
2009年4月19日 · CpG island–like sequences are commonly thought to provide the sole signals for designating constitutively unmethylated regions in the genome, thus generating open …
CpG Island Methylator Phenotype—A Hope for the Future or a …
The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been …
Genome-wide CpG island methylation and intergenic …
We found connections between CGI methylation and hypermutability, microsatellite instability, IDH1 mutation, 19p gain and polycomb features, and backbone demethylation with …
Understanding the interplay between CpG island-associated gene ...
In vertebrates, DNA is pervasively methylated at CG dinucleotides, a modification that is repressive to transcription. However, approximately 70% of vertebrate gene promoters are …
The CpG Island Methylator Phenotype: What's in a Name?
2013年10月1日 · Widespread CpG island promoter methylation, also referred to as the CpG island methylator phenotype (CIMP), was first identified and has been extensively studied in …
Modeling methylation dynamics with simultaneous changes in CpG islands
2020年3月18日 · We propose a probabilistic model (the IWE-SSE model) of methylation dynamics that accounts for simultaneous methylation changes in multiple CpG sites belonging to the …
A Novel CpG Island Set Identifies Tissue-Specific Methylation at …
2008年1月29日 · CpG island methylation, an epigenetic phenomenon usually associated with abnormality in disease, is little characterised in the context of "normal" human cells. Here we …
Primate CpG Islands Are Maintained by Heterogeneous …
2011年5月27日 · Our proposed classification includes the classical unmethylated CpG islands, CpG islands in exons, constitutively methylated CpG islands driven by increased G/C content …
Differential methylation of tissue- and cancer-specific CpG island ...
2009年11月1日 · Here, we find substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine (CpG) island shores in nine human iPS cell lines as compared to their …
Ontogeny of CpG island methylation and specificity of DNMT3 ...
2014年12月3日 · Five percent of CpG islands gain methylation and are found in the promoters of germline genes and in exons of important developmental genes. The onset of global …
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