The Wittig reaction or Wittig olefination is a chemical reaction of an aldehyde or ketone with a triphenyl phosphonium ylide called a Wittig reagent. Wittig reactions are most commonly used to convert aldehydes and ketones to alkenes.
The Wittig Reaction allows the preparation of an alkene by the reaction of an aldehyde or ketone with the ylide generated from a phosphonium salt. The geometry of the resulting alkene depends on the reactivity of the ylide. If R is an electron withdrawing group, then the ylide is stabilized and is not as reactive as when R is alkyl.
2023年1月23日 · The Wittig reaction or Wittig olefination is a chemical reaction of an aldehyde or ketone with a triphenyl phosphonium ylide (often called a Wittig reagent) to give an alkene and triphenylphosphine oxide. The Wittig reaction was discovered in 1954 by Georg Wittig, for which he was awarded the Nobel Prize in Chemistry in 1979.
2023年1月23日 · Organophosphorus ylides react with aldehydes or ketones to give substituted alkenes in a transformation called the Wittig reaction. This reaction is named for George Wittig who was awarded the Nobel …
2007年2月12日 · Over much of its history, the Wittig reaction has been described as a stepwise ionic process. The hypothetical betaine intermediates were never observed, but lithium halide adducts could be isolated in some of the early Wittig experiments. The …
The Wittig reaction, discovered in 1954 by Georg Wittig, is one of the most common tech- niques used for the stereoselective preparation of alkenes. Broadly speaking, the reaction