Thymidylate synthase - Wikipedia
Thymidylate synthase (TS) (EC 2.1.1.45) [5] is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage. [6] [7]
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase catalyzes the synthesis of dTMP from dUMP, which may be generated through phosphorolysis of dUTP formed from UTP or from the deamination of dCTP. An alternative route involves the deamination of dCMP.
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase is an enzyme which catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate or thymidylate) …
Standing the test of time: targeting thymidylate biosynthesis
2014年4月15日 · We overview the pivotal discoveries that led to the rational development of thymidylate biosynthesis as a chemotherapeutic target, and highlight the crucial contribution of these advances to...
Bacterial versus human thymidylate synthase: Kinetics and …
Thymidylate Synthase (TSase) is a highly conserved enzyme that catalyzes the production of the DNA building block thymidylate. Structurally, functionally and mechanistically, bacterial and mammalian TSases share remarkable similarities.
Structural and Functional Characterization of the Human Thymidylate …
Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides the only synthetic source of dTMP, required for DNA biosynthesis. hTS represents a validated target for anticancer chemotherapy.
Folate-Dependent Thymidylate-Forming Enzymes: Parallels …
The first enzyme found to catalyze this fundamental reaction was thymidylate synthase ThyA that uses methylene tetrahydrofolate as carbon source and reducing agent to form thymidylate, an essential DNA precursor.
Thymidylate Synthase - an overview | ScienceDirect Topics
Thymidylate synthase (TS) is an enzyme present in mammalian cells which catalyzes the reductive methylation of deoxyuridylate by 5,10-methylene-5,6,7,8-tetrahydrofolic acid to form thymidylate (dTMP) and dihydrofolic acid.
Thymidylate synthase structure, function and implication in …
Thymidylate synthase (TS or ThyA) has long been considered as one of the best-known drug targets in the anti-cancer area, after which old and new drugs, such as 5-fluoro uracil and the anti-folate ZD1694, have been introduced into chemotherapy to treat solid tumours.
Targeting Nuclear Thymidylate Biosynthesis - PMC
In this review, we examine the mechanisms by which the antifolate 5-fluorouracil, as well as other dTMP synthesis inhibitors, function in cancer treatment in light of emerging evidence that dTMP synthesis occurs in the nucleus.