Th1 and Th2 responses: what are they? - The BMJ
2000年8月12日 · This subset can be further subdivided into Th1 and Th2, and the cytokines they produce are known as Th1-type cytokines and Th2-type cytokines. Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses.
Th1 and Th2 responses: what are they? - PMC - PubMed Central …
This subset can be further subdivided into Th1 and Th2, and the cytokines they produce are known as Th1-type cytokines and Th2-type cytokines. Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses.
Th1 vs Th2 Responses: Mechanisms, Cytokines, and Disease Roles
2024年9月20日 · Explore the distinct roles and mechanisms of Th1 and Th2 responses, their cytokine profiles, and implications in autoimmune and allergic diseases.
TH2 cell development and function | Nature Reviews Immunology
2017年10月30日 · Future single-cell analysis of TCR sequences and cytokine gene expression from individual T H 2 cells, in the context of disease states such as asthma, will significantly augment our...
Recent advances in understanding the Th1/Th2 effector choice
Taken together, the available data indicate that close encounters between bona fide Th1/Th2 cells and Th17 plastic approximations of Th1/Th2 cells, which develop through the Th17 intermediate stage, may occur in vivo.
The paradigm of Th1 and Th2 cytokines | Immunologic Research
In this review, we have discussed the paradigm of Th1 and Th2 cytokines in relation to autoimmunity and allergy. Article PDF Download to read the full article text
TH1 and TH2 cells: a historical perspective - Nature
2002年1月1日 · In this article, I attempt to trace the historical events contributing to the development of the TH1/TH2 concept, the current state of play, and briefly discuss the future prospects for the...
T-cell subsets (Th1 versus Th2) - PubMed
Learning objective: To understand the current status of knowledge in the basic field of polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based on their profile of cytokine production (type 1 or Th1 and type 2 or Th2).
TH1 and TH2 Lymphocyte Development and Regulation of TH …
2004年1月1日 · This article will review the basic factors that control the development of TH1 and TH2 cells, such as the cytokines IL-12 and IL-4 and transcription factors, the possible role of costimulatory molecules, and specialized dendritic cell populations.
Th1/Th2 balance: the hypothesis, its limitations, and ... - PubMed
The Th1/Th2 hypothesis arose from 1986 research suggesting mouse T-helper cells expressed differing cytokine patterns. This hypothesis was adapted to human immunity, with Th1- and Th2-helper cells directing different immune response pathways.