Molecular mechanisms underlying Th1-like Treg generation and …
In this review we give an update on the molecular mechanisms responsible for Th1-like Treg generation focusing on two Treg plasticity aspects: the acquisition of a Th1-suppressing phenotype to control type 1 immune responses, and the acquisition of an effector-like phenotype characterized by their inflammatory nature.
IFNγ-induction of TH1-like regulatory T cells controls antiviral ...
2023年3月16日 · Here the authors show that unlike IL12, IFNγ can induce a T helper 1-like state in regulatory T (Treg) cells during viral infection in mice that suppresses effector T cell responses and memory...
Molecular mechanisms underlying Th1-like Treg generation and …
In particular, recent works have highlighted the acquisition of a Th1-like phenotype by Tregs in several pathological environments. In this review we give an update on the concept of Treg plasticity and the advances in defining the molecular mechanisms that underlie the generation of Th1-like Tregs during an immune response and in different ...
FOXP3 + regulatory T cell perturbation mediated by the IFNγ
2024年1月2日 · IFITM3 and STAT1 are interferon-induced genes that play a positive role in the progression of tumors. Here, we showed that IFITM3-deficient Tregs blunted tumor growth by strengthening the...
Th1-like Treg cells are dressed to suppress anti-tumor immunity
2023年7月11日 · Two studies in Immunity by Ayala et al. and Zagorulya et al. demonstrate that Th1-like Treg cells interact with type 1 dendritic cells in tumors and draining lymph nodes to potently suppress anti-tumor immunity.
IRF8: identity-keeper for suppressive Th1-like Treg cells
2018年5月22日 · Depending on the type of response they control, Treg cells are classified as Th1-like (controlling type I responses), Th2-like (controlling type II responses), or Th17-like (controlling...
IFN-γ-induced Th1-Treg polarization in inflamed brains limits
Among them, T-bet-expressing Tregs are called Th1-like Tregs (Th1-Tregs) and are shown to down-regulate immune responses to tumor and pathogens by suppressing Th1 and CD8 + T cells (27–31). IFN-γ induces polarization from Tregs into Th1-Tregs in vitro and in vivo in tumor-bearing or pathogen-infected mice (23, 28, 29, 31). However, the ...
A genetic method specifically delineates Th1-type Treg cells and …
2023年7月13日 · Okamoto et al. describe a genetic method that allows labeling and removal of a cell population of interest with a higher specificity than existing methods. Utilization of the method highlights the unique features of Th1-type Treg cells and their roles in tumor immunity.
上海市免疫学研究所李斌课题组及合作团队揭示没食子酸诱导Th-1-like Treg …
本研究进一步证实了没食子酸通过抑制Usp21表达来下调FOXP3蛋白水平，并诱导FOXP3lo Treg细胞表达I型炎症因子IFN-γ，从而诱导T-helper-1-like Treg细胞生成（图1）。...
Tissue-specific abundance of interferon-gamma drives regulatory …
2023年2月2日 · Blockade of IFN-γ was sufficient to repolarize Treg cells and rescue CTL responses against lung tumors. Thus, tissue-specific induction of Th1-like Treg cells that suppress DC1-mediated CTL priming could represent a critical barrier to anti-tumor immunity.