Tetrazole - Wikipedia
Tetrazoles are a class of synthetic organic heterocyclic compound, consisting of a 5-member ring of four nitrogen atoms and one carbon atom. The name tetrazole also refers to the parent compound with formula CH 2 N 4, of which three isomers can be formulated.
四唑 - 维基百科，自由的百科全书
四唑 （Tetrazoles）是一种 杂环化合物，含有一个由四氮的五元环，化学式CN 4 H 2。 自然界中尚未发现四唑及其衍生物。 视氢的位置不同，四唑有三种异构体，分别称为1- H，2- H 和5- H -四唑。 其中前两种氮上的氢可以改变位置而互相转化，是一对 互变异构 体，通常讨论的四唑即该平衡偏向的1- H -四唑。 四唑具有芳香性，其离域能为209 kJ·mol -1。 用无水叠氮酸和氢氰酸加压下反应，首次制得了四唑。 [3] 氨基胍 （英语：Pimagedine） 与 亚硝酸钠 在酸性条件下得 5- …
1H-Tetrazole | CH2N4 | CID 67519 - PubChem
1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one- carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole .
Multifaceted Chemistry of Tetrazole. Synthesis, Uses, and ...
2023年2月8日 · Tetrazole is a nitrogen-rich heterocycle possessing both electron-donating and electron-withdrawing properties. The planar structure of tetrazole favors stabilization of electrostatic repulsion of negatively charged ions by delocalization of electrons, which is advantageous for receptor–ligand interactions.
Tetrazoles via Multicomponent Reactions | Chemical Reviews
2019年2月1日 · Here, we review the use of multicomponent reactions for the preparation of substituted tetrazole derivatives. We highlight specific applications and general trends holding therein and discuss synthetic approaches and their value by analyzing scope and limitations, and also enlighten their receptor binding mode.
Tetrazolium Compounds: Synthesis and Applications in Medicine
Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide ...
四唑 - 百度百科
四唑（Tetrazoles）是一种 杂环化合物，含有一个有四氮的五元环，化学式CN4H2。 自然界中尚未发现四唑及其衍生物。 视氢的位置不同，四唑有三种异构体，分别称为1-H，2-H和5-H-四唑。 其中前两种氮上的氢可以改变位置而互相转化，是一对互变异构体，通常讨论的四唑即该平衡偏向的1-H-四唑. 视氢的位置不同，四唑有三种异构体，分别称为1-H，2-H和5-H-四唑。 其中前两种氮上的氢可以改变位置而互相转化，是一对互变异构体，通常讨论的四唑即该平衡偏向的1-H-四 …
Tetrazole - an overview | ScienceDirect Topics
Tetrazole is defined as a compound containing a five-membered ring of four nitrogen, one carbon, and two hydrogen atoms. It is a bioisostere of the carboxylic acid group and is used in drug molecules to enhance lipophilicity, bioavailability, and reduce side effects.
Tetrazoles and Related Heterocycles as Promising Synthetic …
Tetrazole heterocycle is a promising scaffold in drug design, and it is incorporated into active pharmaceutical ingredients of medications of various actions: hypotensives, diuretics, antihistamines, antibiotics, analgesics, and others.
Biologically active compounds and drugs in the tetrazole series …
2021年3月24日 · The review summarizes the advances in medicinal chemistry of tetrazole biologically active compounds and drugs over the past 15 years. Most of the considered compounds are at present actively studied, are in various stages of clinical trials, or have recently been approved for use as pharmaceuticals.
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