The nature of telomere fusion and a definition of the critical telomere …
2007年10月1日 · By using single-molecule approaches to characterize fusion events, we provide a functional definition of fusogenic telomeres in human cells. We show that approximately half of the fusion events contained no canonical telomere repeats at the fusion point; of those that did, the longest was 12.8 repeats.
The ALT pathway generates telomere fusions that can be ... - Nature
2024年1月2日 · Telomere fusions (TFs) can trigger the accumulation of oncogenic alterations leading to malignant transformation and drug resistance. Despite their relevance in tumour evolution, our...
Telomere fusions and translocations: a bridge too far? - PMC
The majority of telomere bridges are proposed to form due to replication-driven telomere loss followed by fusion of the now radically-shortened chromosome end during S-phase of the cell cycle. Thus, G2-phase and mitosis are the only available opportunities for resolution of the fusion prior to cell division.
The nature of telomere fusion and a definition of the critical telomere …
2007年10月1日 · The loss of telomere function can result in telomeric fusion events that lead to the types of genomic rearrangements, such as nonreciprocal translocations, that typify early-stage carcinogenesis. By using single-molecule approaches to characterize fusion events, we provide a functional definition of …
Telomere fusions and translocations: a bridge too far?
2020年2月1日 · The majority of telomere bridges are proposed to form due to replication-driven telomere loss followed by fusion of the now radically shortened chromosome end during S-phase of the cell cycle. Thus, G2-phase and mitosis are the only available opportunities for resolution of the fusion before cell division.
Tracking telomere fusions through crisis reveals conflict …
2021年1月6日 · Progression through crisis was associated with abundant intra-chromosomal telomere fusions with increasing asymmetry and reduced microhomology usage, suggesting shifts in DNA repair capacity. Eroded telomeres also fused with genomic loci actively engaged in transcription, with particular enrichment in long genes.
Telomeres: The Molecular Events Driving End-To-End Fusions
2002年10月29日 · Dating back to the pioneering studies of McClintock, the essential function of telomeres to protect the ends of linear chromosomes has been inferred cytogenetically by the end-to-end fusions and dicentric chromosomes that appear when telomere function is lost (reviewed in [1]).
Telomere dynamics, end-to-end fusions and telomerase ... - Nature
1999年8月3日 · In this study, we performed a detailed cytogenetic and molecular characterization of four SV40 transformed human fibroblastic cell lines by regularly monitoring the size distribution of terminal...
Telomere fusions and translocations: a bridge too far?
2020年2月1日 · Telomere fusions inevitably arise as a cell’s last-ditch effort to protect exposed chromosomal ends when telomeres are lost due to aging-associated erosion, breakage, failed replication, or a plethora of other cellular mistakes.
A Nested PCR Telomere Fusion Assay Highlights the Widespread …
2023年10月20日 · With the aim of detecting both types of fusion events, we have developed a nested PCR method to analyze telomere fusions in Arabidopsis thaliana. This method is simple, accurate, and does not require hybridization.