Influences of Glaucoma on the Structure and Function of …
The RBC makes an excitatory synapse onto the AII AC, which then passes excitatory signals to On CBCs via a gap junction electrical synapse and to Off CBCs via an inhibitory glycinergic …
Insulin restores retinal ganglion cell functional connectivity and ...
2024年8月7日 · We show that daily human recombinant insulin eye drops stimulate retinal ganglion cell (RGC) dendrite and synapse regeneration during ocular hypertension, a risk …
Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma
Synapse loss is observed in neurodegenerative diseases and a complement-driven pruning of synapses on ganglion cells has been proposed in the pathogenesis of glaucoma [8, 12]. In this …
Understanding Glaucoma One Synapse at a Time - PMC
This study adds unprecedented value to glaucoma research. Further work describing cellular and molecular mechanisms behind retinogeniculate synapse dysfunction will be essential to fully …
Retinal ganglion cell dendrite pathology and synapse loss
Retinal ganglion cell (RGC) dendrites receive synaptic inputs from bipolar and amacrine cells, thus allowing cell-to-cell communication and flow of visual information. In glaucoma, damage …
Retinal ganglion cell dendrite pathology and synapse loss: Implications ...
2015年1月1日 · Retinal ganglion cell (RGC) dendrites receive synaptic inputs from bipolar and amacrine cells, thus allowing cell-to-cell communication and flow of visual information. In …
AMPK hyperactivation promotes dendrite retraction, synaptic …
2021年6月29日 · Recent work has implicated energy deficits in glaucoma, and retinal ganglion cell (RGC) dendritic pathology and synapse disassembly are key features of ocular …
Influences of glaucoma on the structure and function of
The influence of glaucoma on RGC synaptic function as well as the mechanisms underlying these effects remain to be determined. Since RGCs are an especially energetically-demanding …
Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma
2015年12月4日 · It has been hypothesized that synaptic pruning precedes retinal ganglion cell degeneration in glaucoma, causing early dysfunction to retinal ganglion cells. To begin to …
The Role of the Classical Complement Cascade in Synapse Loss …
2010年1月1日 · Recent work has implicated the classical complement cascade in the elimination of excess synaptic connections in the developing visual system and in early synapse loss …