SREBF1/SREBP-1 concurrently regulates lipid synthesis and
2023年11月5日 · Our study demonstrates that SREBF1 controls the balance of lipid synthesis, uptake, storage and liberation to maintain lipid homeostasis for rapid tumor growth, while suggesting it as a very promising molecular target for cancer treatment.
SREBF1/SREBP-1 concurrently regulates lipid synthesis and …
Our study demonstrates that SREBF1 controls the balance of lipid synthesis, uptake, storage and liberation to maintain lipid homeostasis for rapid tumor growth, while suggesting it as a very promising molecular target for cancer treatment.
Interplay and cooperation between SREBF1 and master ... - Nature
2021年7月16日 · Taken together, these data shed light on mechanisms of transcriptional dysregulation in cancer, identify specific epigenetic regulators of lipid metabolism, and uncover SREBF1 as a potential...
Interplay and cooperation between SREBF1 and master ... - PubMed
2021年7月16日 · Taken together, these data shed light on mechanisms of transcriptional dysregulation in cancer, identify specific epigenetic regulators of lipid metabolism, and uncover SREBF1 as a potential therapeutic target and prognostic marker in SCC.
SREBP-regulated lipid metabolism: convergent physiology - Nature
2017年8月29日 · In addition to controlling cellular lipid metabolism and homeostasis, sterol regulatory element-binding proteins (SREBPs) act as nodes of convergence and divergence within myriad physiological...
SREBP Regulation of Lipid Metabolism in Liver Disease, and …
SREBP1 expresses two isoforms: SREBP-1a and SREBP-1c, which differ in their first exons due to different transcriptional start sites. SREBP1 isoforms are abundant in the liver, white adipose tissue, adrenal glands, skeletal muscle, and brains of mice and humans, while SREBP2 is expressed ubiquitously [11].
Sterol regulatory element binding transcription factor 1 promotes ...
Sterol-regulatory element-binding protein 1 (SREBP1) is a transcription factor involved in lipid metabolism that is encoded by sterol regulatory element binding transcription factor 1(SREBF1). SREBP1 overexpression is associated with the progression of several human tumors; however, the role of SREBP1 in head and neck squamous cell carcinoma ...
SREBF1 - an overview | ScienceDirect Topics
The three major SREBP isoforms have distinct physiological roles, although their functions overlap to some extent: SREBP1a is involved in overall lipid synthesis, SREBP1c regulates fatty acid synthesis and energy storage, and SREBP2 is specific for cholesterol metabolism regulation.
Deciphering the Role of the SREBF1 Gene in the Transcriptional ...
2024年11月26日 · Sterol regulatory element-binding protein 1 (SREBP1) is an important transcription factor that controls lipid metabolism and adipogenesis. Two isoforms, SREBP1a and SREBP1c, are generated by alternative splicing of the first exon of the SREBF1 gene.
The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism …
2024年1月16日 · Sterol element binding protein 1c (SREBP1c) is the main transcription factor involved in regulating hepatic de novo lipogenesis. This transcription factor is synthesized as an inactive precursor, and its proteolytic maturation is initiated in the membrane of the endoplasmic reticulum upon stimulation by insulin.
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