Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid
2010年4月2日 · Microarray analysis of liver mRNA revealed global changes in the expression pattern of lipid metabolism genes in Sgpl1 −/− mice compared with Sgpl1 +/+ mice. These results demonstrate that S1P lyase expression is a key regulator of sphingolipid levels, and reveals an important influence of the sphingolipid metabolic pathway on lipid ...
Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study …
2016年4月21日 · Here we report an approach using clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated nuclease Cas9 to create a sphingosine-1-phosphate lyase (SGPL1) HeLa knockout cell line to disrupt the …
Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated …
2020年9月1日 · S1P lyase (SGPL1) is a pyridoxal 5’-phosphate-dependent aldehyde-lyase (encoded by the gene SGPL1) which binds sphingosine 1-phosphate (S1P) and catalyses the final and irreversible degradative step in sphingolipid metabolism forming phosphoethanolamine and the long chain aldehyde, hexadecanal (Fig. 1). Up until this point in the pathway ...
The role of sphingosine 1-phosphate metabolism in brain health …
2023年4月1日 · Sphingosine 1-phosphate (S1P) is an evolutionarily conserved catabolic intermediate of sphingolipid metabolism that exerts multiple cellular functions, either intercellularly as a ligand of a subfamily of five G-protein-coupled receptors, named S1PR 1-5, or intracellularly as a secondary messenger (Spiegel & Milstien, 2003).
Mouse Liver Compensates Loss of Sgpl1 by Secretion of …
2021年9月30日 · Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of Sgpl1 in humans and mice leads to accumulation of sphingolipids and multiple organ injuries.
Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis …
Microarray analysis of liver mRNA revealed global changes in the expression pattern of lipid metabolism genes in Sgpl1 −/− mice compared with Sgpl1 +/+ mice. These results demonstrate that S1P lyase expression is a key regulator of sphingolipid levels, and reveals an important influence of the sphingolipid metabolic pathway on lipid ...
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal …
2017年2月28日 · The roles of the bioactive signaling lipid sphingosine-1-phosphate (S1P) and its catabolic enzyme SGPL1/SPL (sphingosine phosphate lyase 1) in autophagy are increasingly recognized. Here we provide in vitro and in vivo evidence for a previously unidentified route through which SGPL1 modulates autophagy in neurons.
Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism …
2022年8月16日 · S1P‐lyase (SGPL1) irreversibly cleaves S1P in the final step of sphingolipid catabolism and exhibits remarkably decreased enzymatic activity in tumor samples. In this study, we used SGPL1‐deficient (Sgpl1 −/−) mouse embryonic fibroblasts (MEFs) and
SGPL1 Gene - GeneCards | SGPL1 Protein | SGPL1 Antibody
2024年12月25日 · SGPL1 (Sphingosine-1-Phosphate Lyase 1) is a Protein Coding gene. Diseases associated with SGPL1 include Reni Syndrome and Nephrotic Syndrome. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and sphinganine-1 …
SGPL1
2019年8月27日 · In this paper we demonstrated a SGPL1 overexpression and mislocalization in pediatric alveolar rhabdomyosarcoma (RMA) cells. Moreover, a homozygous point mutation from A to G at position 321 in...