SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
SREBPs are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, …
Targeting SREBP-1-driven lipid metabolism to treat cancer
Emerging evidence indicates that sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor that controls lipid metabolism, is a critical link between oncogenic signaling and tumor metabolism.
SREBP-regulated lipid metabolism: convergent physiology - Nature
2017年8月29日 · In addition to controlling cellular lipid metabolism and homeostasis, sterol regulatory element-binding proteins (SREBPs) act as nodes of convergence and divergence within myriad physiological...
Sterol regulatory element binding protein 1 couples …
2019年3月22日 · Our results unveil an unpredicted and evolutionary conserved role of SREBP1 in rewiring cell metabolism in response to mechanical cues. Conserved from yeast to humans, SREBPs are transcription...
SIRT1/SREBPs-mediated regulation of lipid metabolism
2024年1月1日 · Sterol regulatory element-binding protein (SREBP) is a substrate of SIRT1 that has attracted significant interest due to its role in multiple cellular processes including cell cycle regulation, DNA damage repair, and metabolic functions.
Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies …
The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) regulates the transcription and translation of SREBP-1 and SREBP-2 to promote de novo lipid biosynthesis in response to nutrients or insulin, which regulate cell proliferation, mitochondrial metabolism, or glycolytic capacity in cancer (49, 50). Similarly, insulin/glutamine ...
SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism ...
2019年1月1日 · To elucidate the mechanism, LXRα inhibitor SR9243 and SREBP1 inhibitor fatostatin were used to verify the role of LXRα and SREBP1 in Cu-induced disorder of lipid metabolism. Both SR9243 and fatostatin significantly attenuated the Cu-induced increase of TG accumulation of hepatocytes.
SREBF1/SREBP-1 concurrently regulates lipid synthesis and
2023年11月5日 · Our study demonstrates that SREBF1 controls the balance of lipid synthesis, uptake, storage and liberation to maintain lipid homeostasis for rapid tumor growth, while suggesting it as a very promising molecular target for cancer treatment.
SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism ...
Taken together, our findings highlight the importance of LXRα and SREBP1 in Cu-induced hepatic lipid deposition, which proposed a novel mechanism for elucidating metal element exposure inducing the disorder of lipid metabolism in aquatic vertebrates.
SREBP-1a–stimulated lipid synthesis is required for macrophage ... - PNAS
2018年12月10日 · In the studies presented here, we show that mTORC1 activates SREBP-1−dependent lipid synthesis to stimulate phagocytosis, whereas prior studies have shown that mTORC1 phosphorylates and inactivates the ULK1 kinase that is essential for early events in formation of the membrane-bound autophagic organelle .