The multi-faceted role of retinoid X receptor in cardiovascular ...
2021年5月1日 · Retinoid X receptors (RXRs) are members of ligand-dependent transcription factors whose effects on a diversity of cellular processes, including cellular proliferation, the …
RXR Agonists Activate PPARα-Inducible Genes, Lower …
Fibrates like gemfibrozil are well-known PPARα activators and are used in the treatment of hyperlipidemia. We show that the RXR ligand LGD1069 (Targretin ™), like gemfibrozil, can …
The role of the retinoid receptor, RAR/RXR heterodimer, in liver ...
2021年5月1日 · In this review, we summarized the functional roles of nuclear receptor RAR/RXR heterodimers in liver physiology. Specifically, RAR/RXR modulate the synthesis and …
TNF and IL-1 Decrease RXRα, PPARα, PPARγ, LXRα, and the …
This study suggests that the decreased expression of nuclear hormone receptors PPARα, PPARγ LXRα, RXRα and their coactivators PGC-1α, PGC-1β, and SRC-1 may be, at least in part, …
Function Annotation of Hepatic Retinoid x Receptor α Based on …
The ratio of UIK and DIK genes in each pathway revealed a distinct role for hepatic RXRα in regulating lipid metabolism and apoptosis. For example, all of the sterol and cholesterol …
RXRα/MR signaling promotes diabetic kidney disease by …
2024年12月1日 · In this study we utilized transcriptomics to reveal the crucial role of RXRα in lipid overload-induced damage in RTECs during DKD. In DKD, RXRα is activated and binds to MR, …
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα ...
2020年3月3日 · Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid …
The role of retinoic acid in hepatic lipid homeostasis defined by ...
2013年8月28日 · Lipid synthesis and metabolism pathways regulated by RA treatment and RXRα deficiency. The diagram represents the effect of RA treatment and RXRα deficiency on the …
RXRα/MR signaling promotes diabetic kidney disease by …
Through high-throughput sequencing, bioinformatic analysis and experimental validation, we confirmed the critical role of RXRα in promoting cell senescence and metabolic dysregulation …
The PPAR-RXR Transcriptional Complex in the Vasculature:
2011年4月15日 · The PPAR-RXR transcriptional complex is a key regulator of proteins central to the handling of energy resources, including transport (lipoprotein metabolism), release …