Phosphatidate-mediated regulation of lipid synthesis at the …
Here, we review the basic steps of lipid synthesis from PA that occurs at the nuclear/ER membrane and summarize the PA-mediated transcriptional regulation for the expression of phospholipid synthesis genes.
Phosphatidate phosphatase, a key regulator of lipid homeostasis
2013年3月1日 · Yeast Pah1p phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol. PAP plays a crucial role in lipid homeostasis by controlling the relative proportions of its substrate phosphatidate and its product diacylglycerol.
Phosphatidic Acid Phosphatase, a Key Enzyme in the Regulation of Lipid ...
Recent genetic and biochemical studies in yeast and mammalian cells have revealed key roles that PAP plays in lipid metabolism and cell physiology. FIGURE 1 Roles of PAP in lipid synthesis and signaling in yeast. The reaction catalyzed by PAH1-encoded PAP …
Roles of phosphatidate phosphatase enzymes in lipid metabolism
Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol ...
Phosphatidate Phosphatase, a Key Regulator of Lipid Homeostasis
Yeast Pah1p phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol. PAP plays a crucial role in lipid homeostasis by controlling the relative proportions of its substrate phosphatidate and its product diacylglycerol.
Phosphatidate phosphatase (PAP, 3-sn-phosphatidate phosphohydrolase, EC 3.1.3.4) catalyzes the dephosphor-ylation of phosphatidate (PtdOH), yielding diacylglycerol (DAG) and inorganic phosphate [1] (Figure 1). PAP enzymes have roles in both the synthesis of lipids and the generation or degradation of lipid-signaling mole-cules in eukaryotic cells.
In de novo biosynthetic pathways, phosphatidate is channeled into mem-brane phospholipids via its conversion to CDP-diacylglycerol. Its dephosphorylation to diacylglycerol is required for the synthesis of triacylglycerol as well as for the synthesis of phosphatidylcholine and phosphatidyletha-nolamine via the Kennedy pathway.
Phosphatidate-mediated regulation of lipid synthesis at the …
2020年1月1日 · Here, we review the basic steps of lipid synthesis from PA that occurs at the nuclear/ER membrane and summarize the PA-mediated transcriptional regulation for the expression of phospholipid synthesis genes.
Phosphatidate-mediated regulation of lipid synthesis at the …
In de novo biosynthetic pathways, phosphatidate is channeled into membrane phospholipids via its conversion to CDP-diacylglycerol. Its dephosphorylation to diacylglycerol is required for the synthesis of triacylglycerol as well as for the synthesis of phosphatidylcholine and phosphatidylethanolamine via the Kennedy pathway.
Roles of phosphatidate phosphatase enzymes in lipid metabolism
2006年12月1日 · Phosphatidate phosphatase (PAP) enzymes catalyze the dephosphorylation of phosphatidate, yielding diacylglycerol and inorganic phosphate. In eukaryotic cells, PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules ...