PFKFB3, a key glucose metabolic enzyme regulated by pathogen ...
Toll-like receptor 4 (TLR4) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3) are involved in the progress of inflammation and glucose metabolism. Here, we aimed to assess the relationship between TLR4 and PFKFB3 in liver cells.
PFKFB3-dependent glucose metabolism regulates 3T3-L1 …
Adipocyte-specific overexpression of PFKFB3 under the control of the AP2 promoter increased lipid storage in adipose tissue, improved insulin resistance and reduced inflammation in high fat fed mice . These data demonstrate a key role for PFKFB3 in adipose tissue development, but do not specifically address the pathway(s).
PFKFB3 protein in adipose tissue contributes to whole body …
2024年12月11日 · A major age-dependent change in adipose tissue is the downregulation of key proteins involved in carbohydrate metabolism. In the current study, we investigate the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) a key governor of the rate of glycolysis in adipocytes via the synthesis of fructose-2,6-bisphosphate that was ...
Molecular Metabolism - ScienceDirect
2019年2月1日 · PFKFB3 has the highest kinase activity to shunt glucose toward glycolysis, whereas PFKFB4 has more FBPase-2 activity, redirecting glucose toward the pentose phosphate pathway, providing reducing power for lipid biosynthesis and scavenging reactive oxygen species.
PFKFB3, a key glucose metabolic enzyme regulated by pathogen …
2020年5月27日 · Aims: Toll-like receptor 4 (TLR4) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3) are involved in the progress of inflammation and glucose metabolism. Here, we aimed to assess the relationship between TLR4 and PFKFB3 in liver cells.
Kinome Screen Identifies PFKFB3 and Glucose Metabolism as …
2015年10月10日 · Results: A kinome siRNA screen identified PFKFB3, a glycolysis regulator, as a modulator of insulin action. Manipulation of PFKFB3 activity or glycolysis affected insulin signaling. Conclusion: Intracellular metabolism modulates important signal transduction pathways.
Our data reveal a critical role for PFKFB3 activity in regulating the cellular metabolic remodeling required for adipocyte differentiation and maturation.
PFKFB3 protein in adipose tissue contributes to whole body …
2024年10月20日 · We employed an adipocyte-specific PFKFB3 mouse line to investigate the role of PFKFB3 on adipocyte function. In both aged mice and PFKFB3-knockout mice, we observed an increase in...
The glycolytic enzyme PFKFB3 drives kidney fibrosis through …
2024年8月1日 · Here, we observed that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a key glycolytic enzyme, was remarkably induced in kidney proximal tubular cells (PTCs) following ischemia-reperfusion injury (IRI) in mice, as well as in multiple etiologies of patients with CKD.
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A ... - PubMed
Major conclusions: PFKFB3 has the highest kinase activity to shunt glucose toward glycolysis, whereas PFKFB4 has more FBPase-2 activity, redirecting glucose toward the pentose phosphate pathway, providing reducing power for lipid biosynthesis and scavenging reactive oxygen species.