PDE3 inhibitor - Wikipedia
A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic shock. Amrinone, milrinone and …
Phosphodiesterase Inhibitors: Types and Purpose - Cleveland Clinic
2022年6月8日 · Phosphodiesterase (PDE) inhibitors are medications that block those enzymes. Some PDE inhibitors are selective, meaning they target a specific type of PDE. Other PDE …
Phosphodiesterase Inhibitors - StatPearls - NCBI Bookshelf
2023年6月26日 · Phosphodiesterase inhibitors (PDE inhibitors) are a class of agents acting on phosphodiesterase enzymes. They are FDA approved to manage chronic obstructive …
Phosphodiesterase Inhibitors: What Are They - Osmosis
2020年11月24日 · PDE3 inhibitors are indicated for the treatment of heart failure, coronary heart disease, and to prevent myocardial infarction. Finally, nonspecific phosphodiesterase inhibitors …
Phosphodiesterase inhibitor - Wikipedia
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular …
Therapeutic targeting of 3′,5′-cyclic nucleotide ... - Nature
2019年8月6日 · Phosphodiesterases (PDEs), enzymes that degrade 3′,5′-cyclic nucleotides, are being pursued as therapeutic targets for several diseases, including those affecting the …
Cilostazol - StatPearls - NCBI Bookshelf
2023年3月27日 · Cilostazol exerts its action by inhibiting phosphodiesterase activity and suppressing cAMP degradation. The inhibition of PDE3 allows for a rise in cAMP in platelets …
Phosphodiesterase inhibitors - Knowledge - AMBOSS
2023年7月14日 · Phosphodiesterase inhibitors are a heterogenic class of drugs that target various isoforms of PDE enzymes. Normally, the PDE decreases cAMP or cGMP in target cells by …
Phosphodiesterase 3 - Wikipedia
PDE3 is clinically significant because of its role in regulating heart muscle, vascular smooth muscle and platelet aggregation. PDE3 inhibitors have been developed as pharmaceuticals, …
How Do PDE-3 Inhibitors Work? - Uses, Side Effects, Drug Names - RxList
PDE-3 inhibitors work by inhibiting the enzyme phosphodiesterase and prevent the breaking down of intracellular secondary messengers, cyclic adenosine monophosphate (cAMP), and cyclic …