Nitric oxide synthase - Wikipedia
Nitric oxide synthases (EC 1.14.13.39) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development.
Nitric Oxide: Physiological Functions, Delivery, and Biomedical ...
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways involved in numerous physiological processes (e.g., vasodilation, neurotransmission, inflammation, apoptosis, and tumor growth).
The L-Arginine-Nitric Oxide Pathway | New England Journal of …
1993年12月30日 · Nitric oxide is synthesized from the amino acid L-arginine by a family of enzymes, the nitric oxide synthases, through a hitherto unrecognized metabolic route -- namely, the...
Nitric Oxide as a Unique Bioactive Signaling Messenger in …
Nitric oxide (NO) is an intra- and extracellular messenger that mediates diverse signaling pathways in target cells and is known to play an important role in many physiological processes including neuronal signaling, immune response, inflammatory response, modulation of ion channels, phagocytic defense mechanism, penile erection, and ...
Human Nitric Oxide Synthase—Its Functions, Polymorphisms, and ...
Enzymes play a major role in the transformations associated with free radicals. One of them is nitric oxide synthase (NOS), which catalyzes the formation of nitric oxide (NO). This enzyme exists in three forms (NOS1, NOS2, NOS3), each encoded by a different gene.
Nitric oxide synthases: regulation and function - Oxford Academic
2011年9月1日 · Mechanisms of nitric oxide synthesis. All isoforms of NOS utilize l-arginine as the substrate, and molecular oxygen and reduced nicotinamide-adenine-dinucleotide phosphate (NADPH) as co-substrates. Flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), and (6R-)5,6,7,8-tetrahydro-l-biopterin (BH 4) are cofactors of all isozymes.
Nitric oxide signaling in health and disease - Cell Press
In mammals, nitric oxide synthase (NOS) exists in three isoforms, all of which generate NO and L-citrulline from L-arginine, molecular oxygen, and NADPH (Figure 1). NOS is a homodimeric heme-containing enzyme with an N-terminal oxygenase domain linked via a calmodulin (CaM)-binding sequence to a C-terminal reductase domain (Stuehr, 1997).
Nitric oxide signalling in kidney regulation and ... - Nature
2021年6月1日 · Nitric oxide (NO) is classically viewed to be formed via the NO synthase (NOS) pathway but can also be generated via a fundamentally different mechanism, the nitrate (NO 3 −)–nitrite (NO 2 −...
Biosynthesis of Nitric Oxide: An Overview | SpringerLink
Soon after the first reports on mammalian nitric oxide (NO) synthesis in 1987 [1, 2], cytosols of cytokine-activated macrophages were shown to contain an enzymatic activity catalyzing an NADPH-dependent conversion of the amino acid L-arginine to NO [3].
Blocking NO synthesis: how, where and why? - Nature
2002年12月1日 · Nitric oxide (NO) is a key physiological mediator, and the association of disordered NO generation with many pathological conditions has led to much interest in pharmacologically modulating NO...