Single-domain antibody - Wikipedia
A single-domain antibody (sdAb), also known as a Nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen.
A guide to: generation and design of nanobodies - PMC
A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are produced recombinantly in micro‐organisms and employed as research tools or for diagnostic and therapeutic applications.
Discovery of nanobodies: a comprehensive review of their …
2024年10月26日 · Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies found in the Camelidae family as well as cartilaginous fish.
NANOBODY® Technology Platform - Sanofi
2021年2月1日 · Discover how Sanofi, through its collaboration with Ablynx, is leading the way in nanobody technology, offering revolutionary treatments in healthcare. These tiny, modular antibodies are ushering in a new era in therapeutics at Sanofi.
NANOBODIES®: A Review of Diagnostic and Therapeutic …
2023年3月22日 · This review will provide an overview, with examples, of (i) the structure and advantages of nanobodies compared to conventional monoclonal antibodies, (ii) methods used to generate and produce antigen-specific nanobodies, (iii) applications for diagnostics, and (iv) ongoing clinical trials for nanobody therapeutics as well as promising ...
Nanobody: A Small Antibody with Big Implications for Tumor …
Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size (~15kDa), excellent solubility, superior stability, ease of manufacture, quick clearance from blood, and deep tissue penetration, which gain increasing acceptance as therapeutical tools and are considered also as buildin...
A guide to: generation and design of nanobodies - PubMed
A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen-binding domain of heavy chain-only antibodies (HCAbs) that are circulating in Camelidae. Nbs are produced recombinantly in micro-organisms and employed as research tools or for diagnostic and therapeutic application …
The Therapeutic Potential of Nanobodies - PMC
Nanobodies are a novel and unique class of antigen-binding fragments, derived from naturally occurring heavy-chain-only antibodies present in the serum of camelids.
Frontiers | Nanobodies: Next Generation of Cancer Diagnostics …
2020年7月22日 · Nanobody are versatile in that their applications extend across the full timeline of a cancer patient's treatment. Using nanobody-based imaging probes has shown improved visualization compared to traditional mAb-based probes.
Recent advances of nanobody applications in diagnosis and …
Nanobodies (Nbs) are the variable domain of heavy-chain antibodies derived from the blood of camelids or sharks. Nanobodies are the smallest antibody fragment with intact antigen-binding ability.