Lipid droplets promote efficient mitophagy - PubMed
We found that iron depletion profoundly rewired the cellular metabolome, remodeling lipid metabolism within minutes of treatment. DGAT1-dependent lipid droplet biosynthesis occurs upstream of mitochondrial turnover, with many LDs bordering mitochondria upon iron chelation.
Mitochondrial degradation: Mitophagy and beyond - ScienceDirect
2023年10月5日 · Mitochondrial degradation pathways contribute to quality control of mitochondrial networks and can also regulate the metabolic profile of mitochondria to ensure cellular homeostasis. Here, we cover the many and varied ways in which cells degrade or remove their unwanted mitochondria, ranging from mitophagy to mitochondrial extrusion.
Mitochondrial degradation: Mitophagy and beyond - Cell Press
2023年9月13日 · Mitochondrial degradation pathways contribute to quality control of mitochondrial networks and can also regulate the metabolic profile of mitochondria to ensure cellular homeostasis. Here, we cover the many and varied ways in which cells degrade or remove their unwanted mitochondria, ranging from mitophagy to mitochondrial extrusion.
Mitochondrial autophagy: molecular mechanisms and implications …
2022年5月9日 · Excessive ROS impacts cellular proliferation and triggers the peroxidation of lipids, impairment of DNA and apoptosis [8]. Mitophagy, as a selective autophagy pathway to mediate the clearance...
Frontiers | The role of mitophagy in metabolic diseases and its ...
2024年1月28日 · Mitophagy, an essential intracellular mitochondrial quality control mechanism, can maintain cellular and metabolic homeostasis by removing damaged mitochondria and participating in developing metabolic diseases. Research has confirmed that exercise can regulate mitophagy levels, thereby exerting protective metabolic effects in metabolic diseases.
Effects of lipids on mitochondrial functions - ScienceDirect
2017年1月1日 · Lipids play a vital role for central processes in mitochondrial biogenesis and metabolism like oxidative phosphorylation, protein import and assembly, membrane architecture and organization as well as mitochondrial dynamics.
Lipid droplets promote efficient mitophagy - Taylor & Francis …
2022年8月8日 · We examined metabolic adaptations in cells treated with deferiprone (DFP), a therapeutic iron chelator known to induce PINK1-PRKN-independent mitophagy. We found that iron depletion profoundly rewired the cellular metabolome, remodeling lipid metabolism within minutes of treatment.
Interplay Between Lipid Metabolism and Autophagy - Frontiers
2020年6月2日 · There is a complex interplay between lipid metabolism (e.g., digestion, absorption, catabolism, biosynthesis, and peroxidation) and autophagy machinery, leading to the modulation of cell homeostasis, including cell survival and death.
Autophagy and hepatic lipid metabolism: mechanistic insight and ...
2024年8月2日 · Autophagy, a cellular catabolic process, has emerged as a primary mechanism of lipid metabolism in mammalian hepatocytes. Furthermore, preclinical studies with autophagy modulators have...
BNIP3 in hypoxia-induced mitophagy: Novel insights and …
2024年3月1日 · Our findings show that hypoxia may activate mitophagy in HFD-induced NAFLD, suggesting that mitophagy in hepatocytes under hypoxic conditions may be an important process involved in lipid metabolism in NAFLD. Mitophagy is the selective autophagic degradation of mitochondria within lysosomes and can be triggered by distinct stimuli such as ...