Methenamine: Uses, Interactions, Mechanism of Action
Methenamine is a urinary tract antiseptic and antibacterial drug used for the prophylaxis and treatment of frequently recurring urinary tract infections requiring a long-term therapy. Methenamine is a heterocyclic organic compound with a …
Methenamine - Wikipedia
Methenamine, also known as hexamine or hexamethylenetetramine and sold under the brand names Hiprex, Urex, and Urotropin among others, is a urinary tract antiseptic and antibacterial medication which is used in the prevention of recurrent urinary tract infections (UTIs).
Methenamine: Dosage, Mechanism/Onset of Action, Half-Life
2020年2月10日 · Methenamine is hydrolyzed to formaldehyde and ammonia in acidic urine; formaldehyde has nonspecific bactericidal action. Other components, hippuric acid or mandelic acid, aid in maintaining urine acidity and may aid in suppressing bacteria.
methenamine (Rx) - Medscape Drugs & Diseases
Indicated for prophylactic or suppressive treatment of frequently recurring urinary tract infections when long-term therapy is considered necessary. Methenamine hippurate: 1 g PO q12hr....
Methenamine Hippurate - an overview | ScienceDirect Topics
Methenamine hippurate works as a bacterial antiseptic. When excreted into the urine, it dissociates to hippuric acid and methenamine. Hippuric acid is bacteriostatic and methenamine is hydrolyzed to ammonia and formaldehyde when in an acidic environment which also has bactericidal properties.
National Center for Biotechnology Information
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Methenamine: a forgotten drug for preventing recurrent urinary …
2014年4月1日 · This article discusses the place of preventive therapy for recurrent UTIs, chemistry, mechanism of action, pharmacology, clinical uses, dosage, adverse reactions and safety, and drug interactions of methenamine.
Methenamine - an overview | ScienceDirect Topics
Methenamine, as the hippurate or mandelate salt to acidify the urine, has a broad spectrum of activity against E. coli, staphylococci, and enterococci, with significant resistance in P. vulgaris and P. aeruginosa. It is used as suppressive or prophylactic therapy in …
Drug therapy reviews: Methenamine mandelate and methenamine hippurate ...
1979年11月1日 · The mechanism of action, spectrum of antimicrobial activity, pharmacokinetics, adverse effects, therapeutic use, and dosage of methenamine hippurate and methenamine mandelate are reviewed. The antimicrobial activity of methenamine depends on its conversion in the urine to formaldehyde.
An oldie but a goodie: Methenamine as a nonantibiotic solution …
2023年6月15日 · Methenamine is as effective in UTI prevention as prophylactic antibiotics with a low side effect burden in randomized, controlled trials. Despite over a century of use, no bacterial resistance mechanisms or increased carcinogenesis have been observed.