p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and …
2010年7月7日 · The human NQO1 promoter, which contains a MARE element with a G to C substitution in the 3′ end that is similar to the p62 MARE, has been shown to be activated or …
Proximity proteomic analysis of the NRF family reveals the ... - AAAS
2023年12月12日 · We used proximity proteomic analysis to define protein networks for NRF2 and its family members NRF1, NRF3, and the NRF2 heterodimer MAFG. A functional screen of co …
NRF2-MAFG binds to the ARE in the p62 promoter in vitro
During Nrf2 activation, p62, an autophagy-related adaptor protein, was phosphorylated at Ser349. Inhibition of the interaction between the phosphorylated p62 and Kelch-like ECH-associated...
SQSTM1/p62 (SQSTM1)靶点介绍及实验小贴士| Abcam中文官网
SQSTM1/p62是与泛素结合的适配器蛋白，可能参与调节TNF-alpha、神经生长因子(NGF)和白细胞介素-1对NFKB1的 激活。 可能参与肌细胞肌动蛋白/TTN下游信号转导。
SQSTM1/p62 Antibody | Cell Signaling Technology
Polyclonal Antibody for studying SQSTM1. Validated for WB. Available in 2 sizes. Highly specific and rigorously validated in-house, SQSTM1/p62 Antibody (CST #5114) is ready to ship.
p62-Keap1-NRF2 通路的激活可防止肝细胞癌细胞中的铁死 …
2015年11月26日 · 在 HCC 细胞中通过 RNA 干扰抑制 p62、醌氧化还原酶-1、血红素加氧酶-1 和铁蛋白重链-1 促进铁死亡，以响应erastin 和索拉非尼。 此外，HCC 细胞中 NRF2 表达/活性 …
MafB regulates NLRP3 inflammasome activation by sustaining p62 …
2023年10月16日 · In this study, we surprisingly found that the RXR activator LG268 increases p62 expression, which is dependent on the upregulation of MafB in macrophages. p62, as it is …
The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment
NRF2 acts as a transcription factor by forming a heterodimer with a small Maf protein (sMaf), including MafF, MafG or MafK, and by binding to the CNC-sMaf-binding element (CsMBE) …
Nrf2 activation through the inhibition of Keap1–Nrf2 …
2020年4月10日 · Compound 13, known as K67, was initially identified as a selective PPI inhibitor of phosphorylated p62 (p-p62) and Keap1 using an FP-based HTS method, targeted for the …
S -acylation of p62 promotes p62 droplet recruitment into ... - Cell …
2023年10月5日 · p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. p62 promotes the assembly and …