Lipid Metabolism in Tumor-Associated Natural Killer Cells
In this chapter, following a general description of NK and TANK cells, our knowledge on the regulation of lipid metabolism in NK cells is reviewed, with an emphasis on the roles of mTOR and SREBP signaling.
Increased lipid metabolism impairs NK cell function and …
2020年12月24日 · We found that NK cells in aggressive B-cell lymphoma underwent substantial transcriptional reprogramming associated with increased lipid metabolism, including elevated expression of the transcriptional regulator peroxisome activator receptor-γ (PPAR-γ).
MEF2C regulates NK cell effector functions through control of lipid ...
2024年4月8日 · We identify myocyte enhancer factor 2C (MEF2C) as a master regulator of human NK cell functionality ex vivo. MEF2C-haploinsufficient patients and mice displayed defects in NK cell...
MEF2C通过调控脂质代谢调节NK细胞的效应功能 - 科学网
2024年4月8日 · 经过不懈努力，他们发现mef2c通过控制脂质代谢调节自然杀伤（nk）细胞的效应功能。 这一研究成果发表在2024年4月8日出版的国际学术期刊《自然 ...
Blood：脂质代谢增强介导了NK细胞在淋巴瘤中的功能受损-MedSc…
近期，Kobayashi等人于《血液》杂志上发表了一篇新研究，其发现NK细胞在侵袭性B细胞淋巴瘤中经历了大量的转录重编程，并伴有脂质代谢增强，包括转录调节因子PPAR-g的表达水平升高。
Metabolic adaptation of NK cell activity and behavior in tumors ...
2023年11月1日 · We discuss cutting-edge concepts in NK cell metabolism, in particular the notion that metabolic substrate flexibility enables NK cells to adapt to different nutrient sources, and their reprogrammed metabolism affects their pharmacology, trafficking, and activation.
Lipid accumulation impairs natural killer cell cytotoxicity and …
2019年8月20日 · In lipid rich environments, NK cells have been recently reported to rapidly accumulate intracellular lipid droplets and undergo metabolic reprograming towards lipid metabolism. Mechanistically, these NK cells displayed suppressed effector function through downregulation of perforin and granzyme mRNA transcripts and significantly reduced IFNγ ...
Metabolic adaptation of NK cell activity and behavior in tumors ...
2023年8月13日 · We discuss the varied and complex drivers of NK cell metabolism in homeostasis and the tumor microenvironment (TME), challenges associated with their targetability, and unexplored therapeutic opportunities. Targeted immune cell-based therapies rely on the precise orchestration of a set of functions by immune cell drugs.
Lipid Metabolism in Tumor-Associated Natural Killer Cells
2021年3月20日 · In this chapter, following a general description of NK and TANK cells, our knowledge on the regulation of lipid metabolism in NK cells is reviewed, with an emphasis on the roles of mTOR and SREBP signaling.
MEF2C regulates NK cell effector functions through control of lipid ...
Supplementation with oleic acid restored MEF2C-deficient and MEF2C-haploinsufficient patient NK cell cytotoxic function. Therefore, MEF2C is a critical orchestrator of NK cell antiviral immunity by regulating SREBP-mediated lipid metabolism.