Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
2021年10月17日 · Caenorhabditis elegans eat bacteria, which consist of lipids, carbohydrates, and proteins that are broken down during digestion into fatty acids, simple sugars, and amino acid precursors. With these nutrients, C. elegans synthesizes a wide range of metabolites that are required for development and behavior.
Application of Caenorhabditis elegans in Lipid Metabolism …
2023年1月7日 · Herein, based on the rapid progress of C. elegans lipid metabolism-related studies, this review outlined the lipid metabolic processes, the major signaling pathways of fat storage regulation, and the primary experimental methods to assess the …
Application of Caenorhabditis elegans in Lipid Metabolism …
2023年1月7日 · Herein, based on the rapid progress of C. elegans lipid metabolism-related studies, this review outlined the lipid metabolic processes, the major signaling pathways of fat storage regulation, and the primary experimental methods to assess the …
C. elegans Fat Storage and Metabolic Regulation - PMC
Many core metabolic pathways found in mammals are well conserved in C. elegans. These include pathways for fatty acid synthesis, elongation and desaturation, mitochondrial and peroxisomal β-oxidation of fatty acids, glycolysis, gluconeogenesis and amino acid …
Perilipin-related protein regulates lipid metabolism in C. elegans
2015年9月1日 · Our data demonstrates that the perilipin-related regulation of fat metabolism is conserved in C. elegans, and provides a novel insight into early embryonic lipid management. This discovery offers promising possibilities for functional studies of lipid metabolism in a nematode model system.
Evolutionarily related host and microbial pathways regulate fat ...
2024年2月19日 · In C. elegans, a tractable model system for lipid metabolism 30 and host-microbe interactions 31, there are three SCD1 homologs 32, including fat-7, which governs the relative abundances of...
Changes in lipid metabolism driven by steroid signalling …
2023年6月5日 · Here, we screen for mutations that might enhance aggregation in Caenorhabditis elegans, to investigate the mechanisms that protect against dysregulated homeostasis. We report that the stomatin homologue UNC-1 activates neurohormonal signalling from the sulfotransferase SSU-1 in ASJ sensory/endocrine neurons.
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
2017年9月29日 · A C. elegans homolog of the mammalian lipid droplet-associated protein CGI-58, called ABHD-5.2 in C. elegans, was shown to coactivate ATGL-1 by tethering it to lipid droplets (Xie and Roy 2015b). In addition, CGI-58/ ABHD-5.2 acts independently of ATGL-1 to prevent fusion of lipid droplets, which might stem from changes in PUFA levels of the ...
Comparative genomics and functional study of lipid metabolic …
2013年3月12日 · In the present study, we systematically analyzed genes involved in lipid metabolism in the C. elegans genome using comparative genomics. We built a database containing 471 lipid genes from the C. elegans genome, and then assigned most of lipid genes into 16 different lipid metabolic pathways that were integrated into a network.
Neuroendocrine Control of Lipid Metabolism: Lessons from C. elegans
Capitalizing on the prescient and pioneering work of Sydney Brenner and John Sulston in establishing C. elegans as an immensely valuable model system, we have uncovered critical roles for oxygen sensing, population density sensing and food sensing in orchestrating the balance between storing lipids and utilizing them for energy in the intestine,...
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