The Role of Lipids and Lipoproteins in Atherosclerosis
2019年1月3日 · It is clear that intestinal lipid processing is a key contributor to the circulating levels of both triglyceride and cholesterol. Dietary, genetic and metabolic factors that disrupt the process of enterocyte lipid metabolism potentially can …
Lipid Metabolism in Macrophages: Focus on Atherosclerosis
2020年8月1日 · In this review, we summarize the existing knowledge on the involvement of macrophage lipid metabolism in atherosclerosis development, including both the results of recent studies and classical concepts, and provide a detailed description of these processes from the moment of lipid uptake with lipoproteins to cholesterol efflux.
Macrophage polarization and metabolism in atherosclerosis
2023年10月20日 · In this review, we discuss the origin of macrophages within plaques, their phenotypic diversity, metabolic shifts, and fate and the roles they play in the dynamic progression of atherosclerosis....
11 Pathogenesis of atherosclerosis: lipid metabolism - Oxford …
Retention of apoB-containing lipoproteins (LDL, IDL, and VLDL) in the arterial intima is the initiating event in the development of atherosclerosis. Retention is mediated by binding of apoB to structural proteoglycans in the intima.
Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus ...
2021年9月6日 · Lipid homeostasis at various levels, including receptor-mediated uptake, synthesis, storage, metabolism, efflux, and its impairments are important for the development of atherosclerosis. The major source of cholesterol and lipid accumulation in the arterial wall is proatherogenic modified low-density lipoprotein (mLDL).
Cholesterol and Lipoprotein Metabolism and Atherosclerosis: Recent ...
2017年11月1日 · Progress in our understanding of lipid, HDL, LDL and VLDL metabolism, as well as the biliary and the non-biliary pathways for removal of cholesterol from the body will greatly increase the likelihood of finding new lipid-lowering therapies and proving that they are more effective in the prevention and therapeutic intervention of cardiovascular ...
Cholesterol and Lipoprotein Metabolism and Atherosclerosis: …
In this review, we summarize the latest advances in the role of the lymphatic route in reverse cholesterol transport, as well as the biliary and the non-biliary pathways for removal of cholesterol from the body.
Cholesterol Metabolism in Atherosclerosis Development
2019年1月1日 · In this chapter, we briefly review how lipids carried by plasma lipoproteins play a role in initiation of atherogenesis and describe the molecular mechanism of lipid metabolism in the atherosclerotic lesion.
Lipid-associated macrophages transition to an inflammatory state …
2023年6月26日 · Our study reveals the cellular basis of lipid-driven inflammation in human atherosclerosis and links it to plaque vulnerability to complications, highlighting new avenues for treatment of...
Apolipoprotein B-containing lipoproteins in atherogenesis
5 天之前 · Apolipoprotein B (apoB) is the main structural protein of LDLs, triglyceride-rich lipoproteins and lipoprotein(a), and is crucial for their formation, metabolism and atherogenic properties. In ...