Lipid metabolism - Wikipedia
Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes.
METABOLOMICS ANALYSIS OF LIPID METABOLIZING ENZYME …
Lipids exert key structural, metabolic, and signaling functions in cells. Lipid diversity found in cells and tissues is regulated principally by metabolic enzymes whose activity is modulated post-translationally to shape head group and fatty acyl composition of membrane lipids.
Lipid metabolic enzymes: emerging drug targets for the
2004年8月1日 · Here we review the main enzymes that are involved in different stages of lipid metabolism — from digestion and absorption through synthesis and storage to mobilization and oxidation — which...
The lipid-metabolism enzyme ECI2 reduces neutrophil ... - Nature
2024年8月21日 · Here, the authors show that the lipid metabolism-related enzyme ECI2 reduces ether-lipid generation leading to decreased neutrophil recruitment and neutrophil extracellular traps formation...
Lipid Metabolism - PMC
Lipids, such as eicosanoids, phosphoinositides, and sphingolipids, serve as signaling molecules. The cholesterol biosynthetic pathway initiates in the cytosol and is controlled by the enzyme 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase), the target of statins (class of cholesterol-lowering drugs). Figure 1.
Lipolysis: cellular mechanisms for lipid mobilization from fat …
2021年11月19日 · In this review, we focus on the mechanisms that facilitate intracellular fatty-acid mobilization, drawing on canonical and noncanonical enzymatic pathways. We summarize how intracellular lipolysis...
Lipases and Lipolysis in Lipid Metabolism and Signaling - Cell Press
2012年3月7日 · Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabolism.
Lipolysis – A highly regulated multi-enzyme complex mediates the ...
Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG) stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty acids, which are subsequently used as energy substrates, essential precursors for lipid and membrane synthesis, or mediators in cell signaling processes.
Enzymes in Lipid Modification - Annual Reviews
This article reviews the application of enzymes in lipid modification. Lipases are the most established biocatalysts used for the synthesis of structured triacylglycerols, fats, and margarine and for the release of flavoring fatty acids for food applications.
Lipid Enzymes: Lipases, Lipoxygenases, and “Hydroperoxidases”
The enzymic pathways by which glyceride lipid is converted into oxygenated fatty acids are reviewed. Sequential reactions start with hydrolysis of glycerides, and the polyunsaturated fatty acids released by lipolysis usually are oxidized enzymically to either …