Zoonoses associated with Laboratory Rodents | Office of …
Laboratory-reared rats and mice are specified pathogen-free and are typically accompanied by a health certificate when purchased from a University-approved source. Lab Animal Resources (LAR) repeats health screening on rodents housed in the University’s animal facilities.
Biology and Diseases of Mice - PMC - PubMed Central (PMC)
Contemporary knowledge about diseases of laboratory mice has developed primarily from examining the effects of disease on traditional strains and stocks. The widespread use of genetically engineered mice is likely to modify current concepts because of novel or unpredictable interactions among genetic alterations, the genetic backgrounds on ...
Natural Pathogens of Laboratory Mice, Rats, and Rabbits and …
Laboratory mice, rats, and rabbits may harbor a variety of viral, bacterial, parasitic, and fungal agents. Frequently, these organisms cause no overt signs of disease. However, many of the natural pathogens of these laboratory animals may alter host physiology, rendering the host unsuitable for many experimental uses.
Infectious Diseases of Mice and Rats - NCBI Bookshelf
The first, Principles of Rodent Disease Prevention, summarizes methods for eliminating infectious agents. It offers information on pathogen terminology; pathogen status of rodents; and breeding, transporting, isolating, testing, and diagnosing rodents.
Mice and Rats as Laboratory Animals - MSD Veterinary Manual
Few infectious agents found in laboratory mice and rats today cause overt, clinical disease. Distinguishing between infection and disease is critical to interpreting the microbiologic status of laboratory animals.
MGI-Mouse Genome Informatics-The international database …
2024年7月15日 · MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. SNP data increased 4-fold. Read more… 🎉MGD 1.0 was released on the World Wide Web 30 years ago. Read more… A new cookie banner appears at the bottom of MGI web pages.
Incidence Rates of Spontaneous Disease in Laboratory Mice …
Spontaneous mortality with unknown cause in adult and neonatal mice without prior reported illness was the most commonly reported issue, followed by dermatitis, ocular disease, and nonspecific clinical signs including lethargy, poor hair coat, and muscle wasting.
Integrating natural commensals and pathogens into preclinical mouse …
2024年11月19日 · Many diseases that are inadequately recapitulated in conventional clean laboratory mice are now studied in mouse models that include natural microbiota and/or pathogens as recently reported at a ...
Research-Relevant Conditions and Pathology of Laboratory Mice, …
The laboratory mouse is the most commonly studied mammal in human disease and basic biology research. 41 The similarities with human genetics, physiology, and anatomy, combined with logistic advantages such as a short lifespan and gestation, high fertility, and available technologies and resources, are favorable for many types of studies. 26 ...
In mice, infection with S. moniliformis typically begins with acute disease consisting of dull, damp hair coats and keratoconjunctivitis. Chronically, mice display variable signs including cutaneous ulceration, arthritis, and gangrenous amputation. Rats do not usually develop any clinical signs of infection. Transmission and Symptoms in Humans: