Hypoxia-Inducible Factor and Oxidative Stress in Tendon …
The study aims to understand the role of tendinopathy-associated hypoxia and its influence on VEGF production, MMP expression, and the biomechanical properties of the tendon in the course of tendinopathy in a rat patellar tendon healing model
Inflammation-related signaling pathways in tendinopathy
2023年9月20日 · In the early stages of tendinopathy, cell necrosis or stimulation by stressful conditions (hypoxia, mechanical) leads to the release of endogenous danger signals or alarmins, resulting in the activation of an immune response.
Hypoxia: a critical regulator of early human tendinopathy
Objectives: To seek evidence for the role of hypoxia in early human tendinopathy, and thereafter to explore mechanisms whereby tissue hypoxia may regulate apoptosis, inflammatory mediator expression and matrix regulation in human tenocytes.
Hypoxia: a critical regulator of early human tendinopathy
The authors propose hypoxic cell injury as a critical pathophysiological mechanism in early tendinopathy offering novel therapeutic opportunities in the management of tendon disorders.
Objectives To seek evidence for the role of hypoxia in early human tendinopathy, and thereafter to explore mechanisms whereby tissue hypoxia may regulate
Hypoxia: A critical regulator of early human tendinopathy
2012年2月1日 · The authors propose hypoxic cell injury as a critical pathophysiological mechanism in early tendinopathy offering novel therapeutic opportunities in the management of tendon disorders.
[PDF] Hypoxia-Inducible Factor and Oxidative Stress in Tendon ...
2024年1月1日 · This review article delves into the contribution of hypoxia-associated genes and oxidative-stress-related factors to tendon degeneration, offering insights into potential therapeutic strategies. Tendinopathy is a debilitating condition marked …
Hypoxia-Inducible Factor and Oxidative Stress in Tendon
2024年1月10日 · This review article delves into the contribution of hypoxia-associated genes and oxidative-stress-related factors to tendon degeneration, offering insights into potential therapeutic strategies. The unique aspect of this study lies in its pathway-based evidence, which sheds light on how these factors can be targeted to enhance overall tendon ...
Tendinopathy and tears of the rotator cuff are associated with hypoxia …
The aim of this study was to investigate the occurrence of tissue hypoxia and apoptosis at different stages of tendinopathy and tears of the rotator cuff. We studied tissue from 24 patients with eight graded stages of either impingement (mild, ...
Hypoxia-Inducible Factor and Oxidative Stress in Tendon ... - MDPI
2024年1月10日 · A well-documented impairment of the HIF-1/vascular endothelial growth factor (VEGF) pathway has been observed in chronic tendon disorders. In tendinopathy, due to elevated hypoxia, HIF-1α expression is upregulated, leading to the promotion of neo-angiogenesis .