Epigenomics Fact Sheet - National Human Genome Research …
2020年8月16日 · What is the epigenome? The epigenome is a multitude of chemical compounds that can tell the genome what to do. The human genome is the complete assembly of DNA (deoxyribonucleic acid)-about 3 billion base pairs - that makes each individual unique. DNA holds the instructions for building the proteins that carry out a variety of functions in a cell.
Human body epigenome maps reveal noncanonical DNA …
2015年6月1日 · Here we report high coverage methylomes that catalogue cytosine methylation in all contexts for the major human organ systems, integrated with matched transcriptomes and genomic sequence.
Epigenome - Wikipedia
In biology, the epigenome of an organism is the collection of chemical changes to its DNA and histone proteins that affects when, where, and how the DNA is expressed; these changes can be passed down to an organism's offspring via transgenerational epigenetic inheritance.
Epigenome: The symphony in your cells | Nature
2015年2月18日 · A large international group of researchers has put together 111 epigenomes from different human cell types, including all the major organs, immune cells and embryonic stem cells.
Salk scientists reveal epigenome maps of the human body’s …
2015年6月1日 · Now, Salk scientists have constructed the most comprehensive maps yet of these chemical patterns–collectively called the epigenome–in more than a dozen different human organs from individual donors (including a woman, man and child).
Human Epigenome Map Yields Insights into Development, Disease
2015年3月9日 · Scientists generated and analyzed more than 100 reference human epigenomes from a broad range of cell and tissue types. Early results revealed epigenomic factors associated with age, sex, tissue type, and various diseases.
Human body epigenome maps reveal noncanonical DNA methylation …
2015年7月9日 · By combining these diverse data types with each individuals' phased genome, we identified widespread tissue-specific differential CG methylation (mCG), partially methylated domains, allele-specific methylation and transcription, and the unexpected presence of non-CG methylation (mCH) in almost all human tissues. mCH correlated with tissue ...
Epigenome Roadmap - Nature
2015年2月18日 · This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results ...
Mapping Human Epigenomes - Cell Press
In this review, we discuss the current epigenome mapping toolkit and utilities of epigenome maps. We focus particularly on mapping of DNA methylation, chromatin modification state, and chromatin structures, and emphasize the use of epigenome maps to delineate human gene regulatory sequences and developmental programs.
The functional genome: epigenetics and epigenomics
2022年1月1日 · This chapter will describe the basic components of the epigenome; how the epigenome is established and maintained; the role of the epigenome in health and disease; and current and future directions in epigenetic and epigenomic research.