Envelope glycoprotein GP120 - Wikipedia
Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. It was discovered by Professors Tun-Hou Lee and Myron "Max" Essex of the …
The GP120 molecule of HIV-1 and its interaction with T cells
The gp120 molecule of HIV-1 is a glycoprotein that is part of the outer layer of the virus. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together …
HIV-1 gp120 as a therapeutic target: Navigating a moving ...
Viral defenses that protect these sites and turn gp120 into a moving labyrinth are discussed together with strategies for circumventing these defenses to allow therapeutic targeting of …
Structural basis of coreceptor recognition by HIV-1 envelope ...
2018年12月12日 · To understand how a coreceptor functions, we have determined the structure of an unmodified CCR5 in complex with a full-length HIV-1 gp120 and a four-domain soluble …
HIV-1 gp120 as a therapeutic target: navigating a moving ...
Despite high-affinity interactions with host receptors and proof-of-principle by the drug maraviroc that interference with CCR5 provides therapeutic benefit, no licensed drug currently targets …
Structure of an HIV gp120 envelope glycoprotein in complex ...
1998年6月18日 · We have solved the X-ray crystal structure at 2.5 Å resolution of an HIV-1 gp120 core complexed with a two-domain fragment of human CD4 and an antigen-binding fragment …
GP120: target for neutralizing HIV-1 antibodies - PubMed
Ongoing crystallographic studies of gp120 molecules from HIV-1 and SIV increasingly reveal how conserved regions, which are the targets of broadly neutralizing antibodies, are concealed …