CN106632217A - (4S, 7RS)-galaxolide synthesis method
The (4S, 7RS)-galaxolide synthesis method is simple in synthetic route and mild in reaction condition, the overall yield reaches 40%, and product optical purity is 91%.
Galaxolide - Wikipedia
Galaxolide has become the key synthetic musk ingredient belonging to the polycyclic musk group as defined by the International Fragrance Association (IFRA). Its odor is described as a “clean”, sweet, floral, woody musk. [5] .
Asymmetric catalysis in fragrance chemistry: a new synthesis of Galaxolide…
2002年10月18日 · A new synthesis of the olfactorally active stereoisomers of the musk odorant Galaxolide® is reported. The key step is the ruthenium-catalysed asymmetric hydrogenation of an α-aryl acrylic acid: asymmetric inductions up to 89% have been achieved using a catalytic system prepared in situ by mixing [Ru(benzene)Cl 2 ] 2 with ( S )-BINAP.
The Synthesis and Application of Galaxolide - Semantic Scholar
This paper discussed the properties,aroma characteristic of Galaxolide,then reviewed its synthetic route,and introduced the application of Galaxolide. 1,1,2,3,3-Pentamethylindane was synthesized by alkylation of tert-amyl alcohol and α–methylstyrene (AMS) using sulfuric acid and sulfolane as catalyst. The effect of the volume of sulfolane on the…
Galaxolide | C18H26O | CID 91497 - PubChem
Musks are synthetic fragrances applied on personal care and household products as fixatives, by retarding the release of other fragrances with higher volatility. Galaxolide is the most used polycyclic musk since the 90th decade, and it has been detected in several environmental and biological matrices, particularly in human tissues and fluids.
ScenTree - Galaxolide® (CAS N° 1222-05-5)
Galaxolide® can be synthesized from tert-amylene by reaction with alpha-methylstyrene, to obtain 1,1,2,3,3-pentamethylindane. This intermediate molecule can be hydroxyalkylated by reaction with the propylene oxide, during a Friedel and Craft reaction, …
Asymmetric catalysis in fragrance chemistry: A new synthesis of Galaxolide…
2002年10月18日 · A new synthesis of the olfactorally active stereoisomers of the musk odorant Galaxolide® is reported.
Disila-Galaxolide and Derivatives: Synthesis and Olfactory ...
2013年7月10日 · A series of silicon-containing derivatives of the polycyclic musk odorant galaxolide (4 a) was synthesized, that is, disila-galaxolide ((4RS,7SR)-4 b/(4RS,7RS)-4 b), its methylene derivative rac-9, and its nor analogue rac-10.
Asymmetric catalysis in fragrance chemistry: a new synthesis of Galaxolide
Synthesis of (+)-3-(4-isopropylphenyl)-2methylpropan-1-ol ((+)-5) Under inert atmosphere, a solution of (+)-4 (150 mg, 0.73 mmol in 10 mL of THF was added dropwise under stirring to a solution of NaBH4 (70 mg, 1.8 mmol in 10 mL of THF).
Asymmetric catalysis in fragrance chemistry: a new synthesis of Galaxolide…
2002年10月18日 · The commercially important isochromane musk odorant Galaxolide® (=1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta [g]-2-benzopyran; HHCB; 3) was separated into its diastereoisomers via the…