Pathology Outlines - Follicular thyroid carcinoma
2017年8月1日 · Minimally invasive follicular carcinoma: very low long term mortality (Cancer 2001;91:505) Widely invasive: 50% long term mortality Poor prognostic factors : tumor size greater than 4 cm, distant metastases, age greater than 45 years, large size, extensive vascular invasion, extrathyroidal extension ( World J Surg 2007;31:1417 )
Pathology Outlines - Papillary thyroid carcinoma overview
2020年1月8日 · There is a growing number of papillary thyroid carcinoma in the last 15 - 20 years due to increasing recognition of thyroid nodules on imaging (ultrasound and CT), sometimes referred as thyroid cancer epidemics; most of these tumors are of low risk (N Engl J Med 2015;373:2389, N Engl J Med 2016;375:614)
Pathology Outlines - Follicular variant
2021年4月20日 · Overall, encapsulated follicular variant has a genomic profile akin to follicular adenoma / follicular carcinoma, whereas infiltrative follicular variant has molecular alterations similar to classic papillary thyroid carcinoma (Eur J Surg Oncol 2018;44:338, Am J Clin Pathol 2003;120:71, Mod Pathol 2010;23:1191, Thyroid 2013;23:1256)
Follicular neoplasm - Pathology Outlines
2022年4月21日 · Invasive follicular variant of papillary carcinoma or noninvasive follicular thyroid neoplasm with papillary-like nuclear features can be represented in this category (Cancer Cytopathol 2016;124:767, Hum Pathol 2016;54:134)
Follicular adenoma - Pathology Outlines
2023年8月14日 · 59 year old woman with metastasis of colonic adenocarcinoma to thyroid follicular adenoma (Pathol Int 2005;55:574) 61 year old man with clear cell follicular adenoma of thyroid (Exp Clin Endocrinol Diabetes 2010;118:19) 61 year old man with follicular adenoma showing spindle cell metaplasia (Am J Surg Pathol 2019;24:84)
Pathology Outlines - Medullary thyroid carcinoma
2018年3月1日 · 66 year old man with thyroid mass (University of Pittsburgh: A Left Thyroid Mass [Accessed 19 March 2018]) 75 year old man with oncocytic variant of medullary thyroid carcinoma (Rare Tumors 2016;8:6537) Encapsulated tumor (Am J Surg Pathol 1991;15:1089)
Pathology Outlines - Oncocytic (Hürthle cell) tumors
2017年10月1日 · No colloid, lymphocytes, histiocytes, plasma cells or ordinary follicular cells Cannot definitively diagnose malignancy based on cytologic material ( Am J Clin Pathol 1993;100:231 , Acta Cytol 2008;52:659 ) but malignant cases tend to have small or large cell dysplasia, nuclear crowding and discohesive cells ( Diagn Cytopathol 2008;36:149 )
Pathology Outlines - Molecular pathology-practical
2023年8月29日 · RAS, PAX8 / PPARγ or BRAF K601E confers 75 - 90% risk of cancer, most likely follicular variant PTC TERT, p53 or PIK3CA mutation predicts thyroid cancer (almost 100% risk), particularly advanced disease with propensity for dedifferentiation and distant metastasis RET M918T is associated with MTC (very high accuracy)
Pathology Outlines - Histology
2009年3月1日 · Follicular cells normally synthesize thyroglobulin and secrete it into follicular lumen Thyroid peroxidase, found in apical membrane of thyroid follicular cells, catalyzes iodination of tyrosine residues on thyroglobulin molecule and coupling of iodotyrosyl residues to form T4 (thyroxine) and T3, which are still bound to thyroglobulin, making ...
Pathology Outlines - Thyroid cancer-general
2009年3月1日 · 1% of all cancer in U.S., 0.2% of all cancer deaths Estimated 56,000 new cases and 1800 deaths in U.S. in 2012 ( SEER ) Increasing incidence due to new diagnostic practices which detect smaller tumors ( Cancer Causes Control 2008;19:585 , BMC Cancer 2006;6:284 , BMC Cancer 2006 Apr 24;6:102 ), although increase may be abating ( Eur J Endocrinol ...