Overview: How Is Alcohol Metabolized by the Body? - PMC
Oxidative pathways of alcohol metabolism. The enzymes alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1), and catalase all contribute to oxidative metabolism of alcohol. ADH, present in the fluid of the cell (i.e., cytosol), converts alcohol (i.e., ethanol) to acetaldehyde.
ALCOHOL METABOLISM - PMC - PubMed Central (PMC)
Rate-limiting steps in the overall metabolism of ethanol, including the activity of alcohol dehydrogenase isoforms, and the necessity to reoxidize NADH by substrate shuttle pathways and the mitochondrial respiratory chain will be discussed.
Ethanol (Alcohol) Metabolism: Acute and Chronic Toxicities
2024年11月20日 · The most significant pathway, responsible for the bulk of ethanol metabolism, is that initiated by alcohol dehydrogenase, ADH. As outlined below, humans express several ADH genes with the class I members being responsible for hepatic ethanol metabolism.
Alcohol Metabolism | National Institute on Alcohol Abuse and …
Alcohol is metabolized by several processes or pathways. The most common of these pathways involves two enzymes—alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). These enzymes help break apart the alcohol molecule, making it possible to eliminate it …
9.2: Alcohol metabolism - Medicine LibreTexts
2021年10月25日 · Metabolism of alcohol occurs primarily in the liver through two different oxidative pathways. The activity of each pathway depends on the ethanol concentration and the frequency of ethanol consumption.
Ethanol Metabolism - an overview | ScienceDirect Topics
Pathways of ethanol metabolism. Ethanol is metabolized mainly by alcohol dehydrogenase (ADH) to produce acetaldehyde. At high levels of ethanol consumption, cytochrome P450 2E1 (CYP2E1) becomes involved in metabolizing ethanol to acetaldehyde. Catalase (CAT) metabolizes ~60% of ethanol within the brain where physiologically active ADH is lacking.
Ethanol Metabolism - SpringerLink
2023年10月21日 · Ethanol, an alcohol found in nature and in alcoholic beverages, is metabolized through complex catabolic pathways. Ethanol is amphiphile and, thus, distributes in all compartments. In addition, there are no negative feedback loops, so that the organism cannot escape from ethanol oxidation.
Genes Encoding Enzymes Involved in Ethanol Metabolism - PMC
The main metabolic pathway for ethanol involves the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Seven different ADHs and three different ALDHs that metabolize ethanol have been identified.
Alcohol metabolism - PubMed
This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the distribution of alcohol in the body, influence the absorption of alcohol, and contribute to first-pass metabol …
In general, alcohol meta bolism is achieved by both oxidative pathways, which either add oxygen or remove hydrogen (through pathways involving ADH, cytochrome P450, and catalase enzymes), and nonoxidative pathways. As shown in Figure 1, ADH, cytochrome P450 2E1 (CYP2E1), and catalase all contribute to oxidative metabolism of ethanol. ADH.