Enterococcus faecium and Ampicillin Susceptibility …
Ampicillin resistance in E. faecium is due to two distinct mechanisms: low-level resistance based on increased quantity of penicillin binding protein 5 (PBP5), which has low affinity for beta-lactams (MIC from 8 to 64 mg/liter), and high-level resistance based on mutation in PBP5 with MICs higher than 16 mg/liter .
Enterococcal Infection—Treatment and Antibiotic Resistance
2014年2月6日 · While the occurrence of ampicillin resistance in E. faecalis has been quite rare, there is now widespread, high-level resistance to ampicillin among clinical E. faecium isolates. High-level aminoglycoside resistance, which negates the synergism between cell-wall active agents and aminoglycosides, has been recognized for several decades.
Antimicrobial Susceptibility Testing for Enterococci - PMC
Importantly, clinical isolates of VR- E. faecium often exhibit resistance to other commonly used antienterococcal antibiotics such as ampicillin and aminoglycosides, raising a major therapeutic challenge (3, 11). Linezolid is the only currently U.S. Food and Drug Administration (FDA)-approved antibiotic for VRE infections.
Resistance to β-lactams in enterococci - ScienceDirect
2019年4月1日 · Ampicillin resistance, which is rare in Enterococcus faecalis, occurs in most of the hospital-associated Enterococcus faecium isolates. High-level resistance to ampicillin in E. faecium is mainly due to the enhanced production of PBP5 and/or by polymorphisms in the beta subunit of this protein.
Genome-Wide Identification of Ampicillin Resistance …
2012年6月28日 · Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance to the β-lactam antibiotic ampicillin has become ubiquitous among clinical isolates.
Antibiotic resistance determination using Enterococcus faecium …
2024年2月1日 · Antibiotic-resistant strains of Enterococcus faecium, especially vancomycin-resistant E faecium, are of particular concern. E faecium is a leading cause of hospital-acquired bloodstream, surgical site, or urinary tract infections, especially in immunocompromised and critically ill patients.
Genome-Wide Identification of Ampicillin Resistance …
Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance to the β-lactam antibiotic ampicillin has become ubiquitous among clinical isolates.
Genome-wide identification of ampicillin resistance determinants …
Enterococcus faecium has become a nosocomial pathogen of major importance, causing infections that are difficult to treat owing to its multi-drug resistance. In particular, resistance to the β-lactam antibiotic ampicillin has become ubiquitous among clinical isolates.
Ampicillin-susceptible Enterococcus faecium infections: clinical ...
2023年9月25日 · Enterococcus faecium is an important human pathogen in which the prevalence of ampicillin resistance is high. However, little is known about the clinical characteristics of patients infected with ampicillin-resistant and ampicillin-susceptible strains.
Mechanisms of Resistance to Imipenem and Ampicillin in Enterococcus …
In E. faecalis, resistance due to mutations in PBPs has not been reported, though it has in Enterococcus faecium. Our results suggest that development of high-level resistance to penicillins and imipenem depends on point mutations of PBP4 at positions 520 and 605.