Overview of DNA methylation in cancer epigenome - Nature
2023年4月28日 · DNA methyltransferase inhibitors (DNMTis) enhance antitumor immunity by inducing transcription of transposable elements and consequent viral mimicry. DNMTis upregulate the expression of...
DNA methylation and cancer - PubMed
It is commonly known that inactivation of certain tumor-suppressor genes occurs as a consequence of hypermethylation within the promoter regions and a numerous studies have demonstrated a broad range of genes silenced by DNA methylation in different cancer types.
Methylomics and cancer: the current state of methylation …
2023年10月16日 · This review thus provides a resource for understanding the emerging role of epigenetic methylation in cancer, the use of methylation-based biomarkers in cancer detection, and novel methylation-targeted drugs.
DNA Methylation and Cancer | Journal of Clinical Oncology
2004年11月15日 · DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Alterations in DNA methylation are common in a variety of tumors as well as in development.
DNA methylation profiles in cancer: functions, therapy, and beyond
2023年12月7日 · Based on the complexity of cancer, DNA methylation changes have wide-ranging effects on the disease landscape, and molecular-targeted treatment of methylation abnormalities has become an effective way to treat cancer.
Navigating the DNA methylation landscape of cancer
2021年6月10日 · DNA methylation is an important epigenetic modification that defines the properties of cells. Genome-wide hypomethylation, as well as hypermethylation of CpG islands associated with tumor suppressor genes and developmental regulators, are …
The DNA methylation landscape in cancer - PubMed
2019年12月20日 · In this review, we describe the distribution of DNA methylation and DNA hydroxymethylation in different genomic contexts, first in normal cells, and how this is altered in cancer. Finally, we discuss DNA methylation profiling technologies and the most recent advances in single-cell methods, bisulfite-free approaches and ultra-long read ...
DNA methylation and human disease | Nature Reviews Genetics
2005年8月1日 · DNA methylation patterns are globally disrupted in cancer, with genome-wide hypomethylation and gene-specific hypermethylation events occurring simultaneously in the same cell. Loss...
DNA methylation landscapes of 1538 breast cancers reveal a ... - Nature
2021年9月13日 · We profiled DNA methylation across 1538 METABRIC breast tumors and performed large-scale integrative analysis of their methylation dynamics in transcriptional, genetic, and clinical contexts.
DNA methylation and cancer: transcriptional regulation, …
2023年1月5日 · Disruption of DNA methylation can cause several diseases, including cancer. Cancer cells can be distinguished by aberrant DNA methylation patterns, generally, two types of DNA methylation take place, which include genome-wide hypomethylation and site-specific hypermethylation [2].