Choline metabolism and its implications in cancer - PMC
In this systematic review, we aim to investigate the relationships between choline metabolism and its implications in cancer through the following three aspects: 1) choline metabolism; 2) current understanding of choline metabolism in cancer; and 3) use of choline-based metabolic imaging for cancer diagnosis and treatment monitoring.
Choline metabolism in malignant transformation - Nature
2011年11月17日 · Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, the modulation of enzymes that control...
Choline Metabolism Provides Novel Insights into Non-alcoholic …
This dietary requirement for choline is modulated by estrogen and by single nucleotide polymorphisms (SNPs) in specific genes of choline and folate metabolism. The spectrum of choline’s effects on liver range from steatosis to development of hepatocarcinomas, and several mechanisms for these effects have been identified.
Choline metabolism provides novel insights into nonalcoholic …
This dietary requirement for choline is modulated by estrogen and by single-nucleotide polymorphisms in specific genes of choline and folate metabolism. The spectrum of choline's effects on liver range from steatosis to development of hepatocarcinomas, and several mechanisms for these effects have been identified.
SLC25A48 controls mitochondrial choline import and metabolism …
Choline metabolism via SLC25A48 plays a key role in mitochondrial respiratory capacity, optimal electron flow, and the maintenance of mitochondrial membrane integrity.
Choline: An Essential Nutrient for Human Health - PMC
Choline is metabolized to trimethylamine (TMA) by gut microbiota in the large intestine and delivered to the liver through the portal circulation system. Individual differences in microbiota composition influence TMA production, which is associated with higher activity of particular phyla such as Firmicutes and Proteobacteria.
Choline metabolism and its implications in cancer - PubMed
2023年11月1日 · Choline, a quintessential quaternary ammonium compound, plays a cardinal role in several pivotal biological mechanisms, chiefly in safeguarding cell membrane integrity, orchestrating methylation reactions, and synthesizing vital neurotransmitters. This systematic review meticulously dissects the com …
An introduction to the nutrition and metabolism of choline
Choline is a ubiquitous water soluble nutrient, often associated with the B vitamins; however, not yet officially defined as a B vitamin. It is important in the synthesis of phospholipid components of cell membranes, and plasma lipoproteins, providing structural integrity as well as being important …
Choline metabolism and its implications in cancer
2023年11月1日 · This systematic review meticulously dissects the complex interplay between choline metabolism and its profound implications in oncology, illuminating the burgeoning potential of choline-centric metabolic imaging modalities, notably magnetic resonance spectroscopy and positron emission tomography, as avant-garde tools for cancer diagnostics and ...
Mapping choline metabolites in normal and transformed cells
2020年11月29日 · This study identifies novel metabolites of choline in cancer and normal cell lines, and reveals altered choline metabolism in cancer cells. Choline is an essential human nutrient that is particular important for proliferating cells, and altered choline metabolism has been associated with cancer