Cellular Senescence in Sarcopenia: Possible Mechanisms and …
2022年1月9日 · Cellular senescence has been implicated in chronic low-grade sterile inflammation, also known as inflammaging in sarcopenia, a hallmark of the ageing process, …
Cellular senescence: the good, the bad and the unknown
2022年8月3日 · Cellular senescence occurs during embryonic development and can be induced by cellular impairment, including DNA damage, telomere shortening or dysfunction, oncogene …
Cellular Senescence in Sarcopenia: Possible Mechanisms and
2022年1月10日 · Cellular senescence refers to the essentially irreversible growth arrest mainly regulated by p53/p21 CIP1 and p16 INK4a /pRB pathways as organism ages, possibly …
Sarcopenia: Molecular Pathways and Potential Targets for …
Chronic inflammation states observed in these pathologies present an increase in circulating pro-inflammatory cytokines, increased presence of dysfunctional T-regulatory cells and a T-cell …
The senescence-associated secretory phenotype and its ... - Nature
2024年4月23日 · In cancer settings, SASP factors secreted by senescent (cancer) cells into the tumour microenvironment can promote tumour-suppressive paracrine senescence or …
Single nuclei profiling identifies cell specific markers of skeletal ...
At the cellular level, senescence is a cell fate that typically entails cell cycle arrest and a complex senescence-associated secretory phenotype (SASP) that can be induced by myriad stresses, …
Cellular Senescence: The Driving Force of Musculoskeletal Diseases
Cellular senescence contributes to the aging of muscle tissue and the onset of sarcopenia. Cellular senescence in sarcopenia is a process in which specific senescence markers, such as …
Cellular senescence in musculoskeletal homeostasis, diseases, and ...
2021年9月10日 · Tocotrienol-rich fraction treatment of patients with sarcopenia has been shown to reverse myoblast aging and senescence, providing muscle cells with the regenerative …
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and ...
2020年6月2日 · Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength, and functions in elderly people. It is accompanied by physical frailty, functional …
Cellular senescence in musculoskeletal homeostasis, diseases, …
2021年9月10日 · Cellular senescence is therefore a defining feature of age-related musculoskeletal disorders, and targeted elimination of these cells has emerged recently as a …