Carbapenemase Carbapenem Antibiotic Resistance Enzyme. Carbapenemase …
Carbapenemase carbapenem antibiotic resistance enzyme. Carbapenemase OXA-24 from the bacterium Acinetobacter baumannii. Illustration about oxa24, betalactamase, infection - 188465521
Carbapenemases- Definition, Types, Significance, Bacteria
2023年5月12日 · Carbapenemases are the β-lactamase enzymes that hydrolyze most of the β-lactam antibiotics, including carbapenems. They are the most potent β- lactamases having a very wide spectrum of activity against penicillins, cephalosporins, monobactams, and carbapenems.
Carbapenems: Past, Present, and Future - PMC - PubMed Central …
2011年8月22日 · Among the β-lactams currently available, carbapenems are unique because they are relatively resistant to hydrolysis by most β-lactamases, in some cases act as “slow substrates” or inhibitors of β-lactamases, and still target penicillin binding proteins.
High level non-carbapenemase carbapenem resistance by …
2024年11月18日 · Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mexR , oprD , and ftsI to carbapenem resistance in P. aeruginosa during in vivo evolution studies with consecutive ...
Carbapenemase genes and genetic platforms in Gram-negative …
2014年9月1日 · Carbapenemases are enzymes that inhibit almost all β-lactam antibiotics, including carbapenems, and have now been reported mainly in Enterobacteriaceae, A. baumannii, and P. aeruginosa [4].
Understanding Carbapenemases: Types, Actions, Detection, …
2024年11月30日 · Carbapenemases are enzymes that threaten public health by conferring resistance against carbapenems, a class of last-resort antibiotics. The rise in carbapenemase-producing bacteria complicates infection treatment and …
Global spread of carbapenem-resistant Enterobacteriaceae ...
2023年1月1日 · Carbapenem-resistant Enterobacterales (CRE) was one of top three drug-resistant bacteria in urgent need of new antibiotics. The molecular epidemiological features, resistance mechanisms, detection and therapy of CRE were reviewed.
Structural Basis for Carbapenem-Hydrolyzing Mechanisms of ...
2015年4月29日 · We update recent studies in understanding the enzymatic mechanism of each class of carbapenemase, and summarize structural insights about regions and residues that are important in acquiring the carbapenemase activity.
Carbapenem Resistance: A Review - MDPI
Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by transferable carbapenemase-encoding genes.
Carbapenemase-Producing Organisms: A Global Scourge
2018年4月3日 · The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern. Carbapenemase production is especially problematic when encountered in members of the family Enterobacteriaceae. Due to their ability to readily spread an …