Burkitt’s Lymphoma | New England Journal of Medicine
2022年9月21日 · The molecular hallmark of Burkitt’s lymphoma is the t(8;14) translocation of MYC from chromosome 8 to the immunoglobulin heavy-chain region on chromosome 14, in 70 to 80% of cases; the...
Translocations involving 8q24 in Burkitt lymphoma and other
2008年10月16日 · Burkitt lymphoma (BL) has a characteristic clinical presentation, morphology, immunophenotype and primary chromosomal aberration, that is, the translocation t(8;14)(q24;q32) or its variants.
Burkitt lymphoma - Wikipedia
Almost all cases of Burkitt lymphoma are characterized by dysregulation of the c-myc gene by one of three chromosomal translocations which place the myc gene under the control of an immunoglobulin gene enhancer.
Burkitt lymphoma - Genes and Disease - NCBI Bookshelf
Burkitt lymphoma results from chromosome translocations that involve the Myc gene. A chromosome translocation means that a chromosome is broken, which allows it to associate with parts of other chromosomes. The classic chromosome translocation in Burkitt lymophoma involves chromosome 8, the site of the Myc gene.
Burkitt Lymphoma - StatPearls - NCBI Bookshelf
2023年8月7日 · Burkitt lymphoma (BL) is an aggressive non-Hodgkin B-cell lymphoma. The disease is associated with Epstein Barr virus (EBV), human immunodeficiency virus (HIV), and chromosomal translocations that cause the overexpression of oncogene C-MYC. The World Health Organization (WHO) classifies BL into three clinical groups: endemic, sporadic and ...
Translocations Involving 8q24 in Burkitt Lymphoma and Other …
2008年11月16日 · Burkitt lymphoma (BL) has a characteristic clinical presentation, morphology, immunophenotype and primary chromosomal aberration, i.e. the translocation t(8;14) (q24;q32) or its variants. However, diagnostic dilemmas may arise in daily practice due to overlap of BL with subsets of other aggressive, mature B cell lymphomas such as a small subset ...
Translocations involving 8q24 in Burkitt lymphoma and other ... - PubMed
Burkitt lymphoma (BL) has a characteristic clinical presentation, morphology, immunophenotype and primary chromosomal aberration, that is, the translocation t(8;14)(q24;q32) or its variants. However, diagnostic dilemmas may arise in daily practice due to overlap of BL with subsets of other aggressiv …
Pathobiology of Burkitt lymphoma - UpToDate
2023年11月28日 · Burkitt lymphoma (BL) is a highly aggressive B cell neoplasm characterized by the translocation and deregulation of the MYC gene on chromosome 8. Three distinct clinical forms of BL are recognized: endemic, sporadic, and immunodeficiency associated.
Burkitt Lymphoma Genetic Causes: Translocation
2021年8月5日 · In people with Burkitt lymphoma, the chromosome translocation causes c-MYC to move to a different chromosome, next to a gene called immunoglobulin heavy chain (IgH). Lymphocytes frequently need to turn on this immunoglobulin gene to make antibodies (infection-fighting proteins).
Translocation Tales: Unraveling the MYC Deregulation in Burkitt ...
Chromosomal Translocations: In Burkitt lymphoma (BL), the most common mechanism of MYC deregulation involves chromosomal translocations that place the MYC gene under the control of immunoglobulin (Ig) enhancer elements, leading to constitutive activation of MYC expression in B-cells [34,35,36,37].
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