Amyloid beta - Wikipedia
Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's …
Amyloid beta: structure, biology and structure-based …
2017年7月17日 · Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases.
Amyloid Beta Peptide - StatPearls - NCBI Bookshelf
2023年8月28日 · Amyloid beta peptide is a 42-amino acid peptide and derives from the precursor protein, amyloid beta precursor protein (APP). The amyloid beta precursor protein is a …
What is the Physiological Function of Amyloid-Beta Protein?
2019年2月8日 · Most of the studies of amyloid-beta (Aβ) have concentrated on the pathological effects of high levels of the protein in causing cognitive impairment and Alzheimer’s disease …
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · Here, we systematically review and update the vast state-of-the-art literature of Aβ science with evidence from basic research studies to human genetic and multi-modal …
Insights into the physiological function of the β-amyloid …
This article reviews studies on the structure, expression and post-translational processing of β-amyloid precursor protein (APP), as well as studies on the effects of APP in vitro and in vivo. …
Insights into the physiological function of the β-amyloid …
The β-amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the β-amyloid protein (Aβ) of Alzheimer's disease. However, the normal function of APP …
Amyloid beta: structure, biology and structure-based therapeutic ...
In this paper, we review the structures, biological functions, and neurotoxicity role of Aβ. We also discuss the potential receptors that interact with Aβ and mediate Aβ intake, clearance, and …
β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s …
2015年9月30日 · Aβ is generated from amyloid precursor protein through sequential cleavage of β- and γ-secretases while Aβ removal is dependent on the proteolysis and lysosome …
Biology of amyloid: structure, function, and regulation
2010年10月13日 · Amyloids are highly ordered cross-β sheet protein aggregates associated with many diseases including Alzheimer's disease, but also with biological functions such as …