PI3K/AKT/mTOR pathway - Wikipedia
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. [1] .
PI3K/AKT/mTOR signaling transduction pathway and targeted
2023年8月18日 · The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions w …
PI3K Akt 通路 | Cell Signaling Technology
Akt 通过作用于 TSC1/TSC2 复合体以及 mTORC 信号转导，进而调节细胞生长。 Akt 通过磷酸化 CDK 的抑制剂 p21 和 p27，进而影响细胞增殖。 Akt 是细胞存活的主要调节因子，通过直接抑制促凋亡蛋白（如 Bad）或抑制由转录因子（如 FoxO）产生促凋亡信号实现调节。 Akt 通过激活 AS160 和 PFKFB2，对调节代谢发挥重要作用。 另外，已有证据显示，Akt 可调节参与神经功能的多种蛋白，包括 GABA 受体、ataxin-1 和 huntingtin 蛋白。 Akt 通过磷酸化 palladin 和 …
PI3K/AKT/mTOR 通路 (PI3K/AKT/mTOR pathway) - Abcam中文 …
PI3K/AKT/mTOR 通路是一种细胞内信号传导通路，参与多个生物学过程，例如细胞增殖、凋亡、血管生成和葡萄糖代谢 1,2。 细胞外生长因子与跨膜受体酪氨酸激酶（RTK），例如 EGFR 3,4，结合后会激活该通路，随后磷脂酰肌醇 3-激酶（PI3K）和丝氨酸/苏氨酸蛋白激酶 B（PKB/AKT）也被激活，从而导致一系列下游底物发生丝氨酸和/或苏氨酸磷酸化，这些下游底物通常是激酶/磷酸酶或介导各种细胞作用方式的其他信号分子。 该通路的失调与多种人类疾病 …
Targeting the PI3-kinase/Akt/mTOR Signaling Pathway - PMC
The PI3K/Akt/mTOR pathway can be targeted by a variety of approaches including: (i) targeting kinases that lead to activation of Akt, PI3K and PDK-1, (ii) directly targeting PI3K, (iii) directly inhibiting Akt, (iv) targeting downstream effectors of Akt …
PI3K/AKT/mTOR signaling transduction pathway and targeted …
2023年8月18日 · The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression. Growth factor signalling to transcription factors in the PAM axis is highly regulated by multiple cross-interactions with several other signaling pathways, and ...
PI3K/AKT/mTOR signaling pathway: an important driver and
2024年4月17日 · The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) growth, survival, proliferation, and angiogenesis, which could be an interesting therapeutic target.
Targeting PI3K/Akt signal transduction for cancer therapy
2021年12月16日 · In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination therapies...
Targeting PI3K/Akt/mTOR Signaling in Cancer - Frontiers
2014年4月13日 · The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways are both crucial to many aspects of cell growth and survival, in physiological as well as in pathological conditions.
Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer ...
Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in the regulation of cell survival, growth, and proliferation. Irregularities in the major components of the PI3K/AKT/mTOR signaling pathway are common in human cancers.