Structure and Dynamics of the Acyl Chains in the Membrane ... - PubMed
2019年11月19日 · Specifically, recent findings indicate a crucial interplay between the level of saturation of the lipid tail, its energetically and sterically favored conformations, and the …
Lipid saturation controls nuclear envelope function
2023年8月17日 · Here we discover lipid acyl chain unsaturation as essential for NE and nuclear pore complex (NPC) architecture and function. Increased lipid saturation rigidifies the NE and …
Lipid classification, structures and tools - PMC - PubMed Central …
The MS prediction tools for glycerolipids and glycerophospholipids have been extended by computing product ion masses for commonly observed fragments corresponding to acyl chain …
Acyl-chain saturation regulates the order of phosphatidylinositol …
2021年11月29日 · Here, we report the impact of acyl-chain structure on the biophysical properties of cation-induced PI (4,5)P 2 nanodomains. PI (4,5)P 2 species with increasing levels of acyl …
Plasma membranes are asymmetric in lipid unsaturation, packing …
2020年5月4日 · However, advances in lipidomics have revealed a vast diversity of lipid species in mammalian membranes, comprising hundreds of lipid species with distinct headgroups, acyl …
Lipid unsaturation and organelle dynamics - ScienceDirect
2016年8月1日 · The number of double bonds (=unsaturation) in the acyl chains of phospholipids (PL) influences the physical properties of cellular membranes. Here, we discuss disparate …
Lipid Acyl Chain cis Double Bond Position Modulates Membrane …
2019年9月18日 · Here, we revealed that lipid acyl chain cis double bond position can regulate the inter-leaflet coupling according to our coarse-grained and all-atom molecular dynamics …
Phospholipid Acyl Chain Diversity Controls the Tissue-Specific …
2020年3月24日 · The promiscuity of many (phospho)lipid metabolic reactions can transfer acyl chain specificity from one lipid pool to another. As these couplings harbor the potential to be …
Beyond Fluidity: The Role of Lipid Unsaturation in Membrane …
Lipids with one saturated acyl chain and one polyunsaturated acyl chain (e.g., 18:0–22:6 PC) provide the best trade-off between keeping membrane permeability low, while enabling fast …
Lipids display structural diversity in their acyl chains. To elucidate the effect this diversity has on lipid trafficking, Schmieder et al. synthesize a glycosphingolipid (GM1) library with varied fatty …