2-Aminoanthracene | C14H11N | CID 11937 - PubChem
The occurrence of an amino group on the anthracene structure, is predicted to cause 2-anthracenamine to photolyze faster than anthracene which has an estimated near-surface photolysis half-life (latitude 40 deg N, midday, midsummer) of 4.5 days in water(3,SRC). 2-Anthracenamine contains no hydrolyzable functional groups, and therefore, is not ...
Inflammatory effect of 2-aminoanthracene (2AA) on adipose …
2-Aminoanthracene (2AA), a PAH, is a known carcinogen. This aromatic amine occurs naturally and in synthetic form. 2AA is also a teratogen that may cause mutations which may lead to birth defects or malformations (Boudreau et al., 2006).
The Quorum Sensing Volatile Molecule 2-Amino Acetophenon
2012年11月15日 · Here, we show that the Pseudomonas aeruginosa QS-regulated molecule 2-amino acetophenone (2-AA) modulates host immune responses in a manner that increases host ability to cope with this pathogen. Mice treated with 2-AA prior to infection had a 90% survival compared to 10% survival rate observed in the non-pretreated infected mice.
Reactive enamines and imines in vivo : Lessons from the RidA …
Multiple PLP-dependent α,β-eliminases use α-amino acid substrates to generate and release enamine intermediates, specifically 2-aminoacrylate (2AA). In the absence of RidA, 2AA accumulates and damages PLP-dependent enzymes through covalent modification.
Digital Commons@Georgia Southern - GS4 Georgia Southern …
2015年4月24日 · We have previously observed insulin-signaling related altered gene expression in animals exposed to 2AA. 2AA is an amino-substituted polycyclic aromatic hydrocarbon used in manufacturing dyes, chemical, inks, resins, and polyurethanes. 2AA is a known mutagen and carcinogen that occurs naturally and can be found in tobacco smoke and cooked foods.
Inflammatory effect of 2-aminoanthracene (2AA) on adipose ... - PubMed
Previously we reported insulin-signaling related altered gene expression in animals exposed to 2-Aminoanthracene (2AA). 2AA is an amino-substituted polycyclic aromatic hydrocarbon used in manufacturing dyes, chemicals, inks, resins, and polyurethanes.
Integrated Metabolomics and Transcriptomics Suggest the Global ...
Some pyridoxal 5′-phosphate (PLP)-dependent enzymes catalyze the β-elimination of 3-carbon α-amino acids, generating and releasing a reactive enamine product, 2-aminoacrylate (2AA). 2AA can be hydrolyzed to pyruvate by a non-enzymatic, or RidA catalyzed process.
综合的代谢组学和转录组学研究表明，沙门氏菌对2-氨基丙烯酸酯 …
In Salmonella enterica, 2-aminoacrylate (2AA) is a reactive enamine intermediate generated during a number of biochemical reactions. When the 2-iminobutanoate/2-iminopropanoate deaminase (RidA; EC: 3.5.99.10) is eliminated, 2AA accumulates and inhibits the activity of multiple pyridoxal 5'-phosphate (PLP)-dependent enzymes.
Here, we report that STAT3 plays a key role in amino acid dampening of insulin signaling in hepatic cells. Excess amino acids inhibited insulin-stimulated Akt phosphor-ylation and glycogen synthesis in mouse primary hepatocytes as well as in human hepatocarcinoma HepG2 cells.
2-Aminoacrylate in the context of branched-chain amino acid …
In Salmonella enterica, the absence of the RidA deaminase results in the accumulation of the reactive enamine 2-aminoacrylate (2AA). The resulting 2AA stress impacts metabolism and prevents...