Xenobiotic - Wikipedia
Many xenobiotics produce a variety of biological effects, which is used when they are characterized using bioassay. Before they can be registered for sale in most countries, xenobiotic pesticides must undergo extensive evaluation for risk factors, such as toxicity to humans, ecotoxicity, or persistence in the environment. For example, during ...
Xenobiotics: Interaction with the Intestinal Microflora - PMC
Combining well-designed animal models and exposure scenarios would allow us to discover the mechanisms behind how xenobiotics-induced microbiome alterations, GM-mediated production of toxic metabolites, or the perturbations to metabolic/detoxification pathways can actually disrupt human health, which currently represents a significant knowledge ...
Chemical transformation of xenobiotics by the human gut …
2017年6月23日 · The range of xenobiotics subject to gut microbial metabolism is impressive and expanding. Gut microbes modify many classes of dietary compounds, including complex polysaccharides, lipids, proteins, and phytochemicals. These metabolic reactions are linked to a variety of health benefits, as well as disease susceptibilities.
Microbial transformation of dietary xenobiotics shapes gut …
2024年9月24日 · To understand the scope and principles of interactions between the gut microbiome and dietary xenobiotics, we sought to systematically map the effects of chemically diverse dietary xenobiotics on bacterial growth and community composition and profile the capacity of diverse gut microbes and microbial communities to chemically modify these ...
The gut microbiome: an orchestrator of xenobiotic metabolism
2020年1月1日 · The bioavailability of xenobiotics can be influenced by altered host intestinal permeability, mucus layer thickness, or through direct interaction of compounds with bacteria. To date, microbial influences on absorption have been …
Exposure to environmental pollutants selects for xenobiotic …
2024年5月27日 · Here we demonstrate the dramatic effect that environmental xenobiotics have on gut microbial communities, shaping their composition and boosting the selection of strains with degrading capacity.
Studies of xenobiotic-induced gut microbiota dysbiosis: from ...
Linking those mechanistic pathways with xenobiotic exposure not only can elucidate the specific effects of xenobiotics on gut microbiota and help us better evaluate the toxicity and health effects of xenobiotics, but also can provide valuable targets for the development of microbiota-based new intervention approaches and therapies.
Microbial transformation of dietary xenobiotics shapes gut
2024年10月31日 · Microbial metabolism can toxify and detoxify these compounds, producing emergent interactions that explain community-specific remodeling by dietary xenobiotics. We identify the gene and enzyme responsible for detoxification of one such dietary xenobiotic, resveratrol, and demonstrate that this enzyme contributes to interindividual variation in ...
Exploring Next Generation Probiotics for Metabolic and …
2022年10月26日 · The interactions between environmental xenobiotics, human gut microbiota, microbial metabolites and host status are highly complex and require holistic approaches to better understand how the gut microbiome and derived metabolites affect host development, health, and disease occurrence.
Recent review on selected xenobiotics and their impacts on gut ...
2023年9月1日 · Investigation of both microbial and host metabolites is a promising approach to accurately evaluate the toxicity of xenobiotics and develop therapeutic targets. In this review, we will summarize the recent advancements in metabolomics, especially those studies related to toxic xenobiotics using in vivo and in vitro biological models. Notably ...