Hematopoietic stem cell (HSC) divisional memory: The journey of ...
2021年4月1日 · The model of a progressive HSC functional decline with subsequent cell divisions raises several intriguing questions: Does cellular division memory exist, and if so, what carries this memory from cell to cell to permanently change HSC functions and determine the life span of …
Hepatic Stellate Cell Membrane-Camouflaged Nanoparticles for …
2024年11月25日 · Here, we developed an HSC membrane-camouflaged nanosystem, named HSC-PLGA-BAY, for the precise delivery of the antifibrosis agent BAY 11-7082 to activated HSCs in the treatment of liver fibrosis. The designed HSC-PLGA-BAY nanosystem exhibited selective targeting toward activated HSCs, with internalization mediated by homologous cell adhesion ...
The multifaceted role of mitochondria in HSC fate decisions: …
2023年12月1日 · Mitochondria are emerging as critically important for HSC quiescence, cell cycle initiation, and for HSC fate decisions during cell division. Yet, we still do not know exactly which metabolites are produced by mitochondria, how they are used, and in which context.
Membrane-bound SCF and VCAM-1 synergistically regulate the …
2021年10月10日 · Hematopoietic stem cells form a polarized morphology with enhanced adhesion and improved nuclear FOXO3a on membrane-bound SCF and VCAM-1 on a lipid bilayer. The work reveals a unique role of the niche membrane-bound factors in stem cell anchorage and maintenance.
Hepatic Stellate Cells in Physiology and Pathology - PMC
Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury. HSCs are primarily known for their activation upon liver injury and producing the collagen-rich extracellular matrix in liver fibrosis.
HEMATOPOIESIS AND STEM CELLS - ScienceDirect
2021年8月12日 · We surveyed 16 published and unpublished data sets to determine whether a consistent pattern of transcriptional deregulation in aging murine hematopoietic stem cells (HSC) exists. Despite substantial heterogeneity between individual studies, we uncovered a core and robust HSC aging signature.
Regulation of the hematopoietic stem cell pool by C-Kit ... - Science
2024年8月9日 · We uncovered a definable pool of mobilizable stem cells and demonstrated that membrane-fragment transfer from macrophages could be functionalized by HSCs for BM retention. Our study provides proof of concept that adult stem cells can utilize trogocytosis to establish and activate function-modulating molecular mechanisms rapidly.
The Power of Plasticity—Metabolic Regulation of Hepatic ... - Cell …
In this review, we integrate emerging insights into HSC energetics, its crosstalk with cellular stress responses, and non-cell autonomous effects on liver homeostasis and immunometabolism to demonstrate how metabolic regulation of HSCs underlies their functions in health and disease, revealing a rich and wide-ranging biology.
A mitochondrial NADPH-cholesterol axis regulates ... - Cell Press
2024年3月7日 · Ito et al. investigate the mechanism by which mitochondrial metabolism controls hematopoietic stem cell (HSC) fate. They reveal that FAO (fatty acid oxidation)-generated NADPH fuels cholesterol biosynthesis in HSCs.
HSC Book Flashcards - Quizlet
Study with Quizlet and memorize flashcards containing terms like Organelle, What is a membrane composed of?, What tasks do cell membranes perform? and more.