Nucleoside analogue - Wikipedia
Nucleoside analogues are structural analogues of a nucleoside, which normally contain a nucleobase and a sugar. Nucleotide analogues are analogues of a nucleotide, which normally has one to three phosphates linked to a nucleoside.
Nucleoside Analogues - PubMed
2020年5月1日 · The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella-zoster (VZV) infection.
Nucleoside Analogues - LiverTox - NCBI Bookshelf
2020年5月1日 · The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella-zoster (VZV) infection.
Nucleoside Analogs: A Review of Its Source and Separation …
Nucleoside analogs play a crucial role in the production of high-value antitumor and antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation.
Nucleoside analogues: N-glycosylation methodologies, synthesis …
2023年10月1日 · Nucleoside analogues may be synthesized through multiple synthetic pathways, however the N-glycosylation of a nucleobase is the most common method. Amongst the different classical N -glycosylation methodologies, the Vorbrüggen glycosylation is …
Nucleotide and nucleoside-based drugs: past, present, and future
2022年12月1日 · Nucleoside analogues are an introductory class of antiviral agents commonly used in the therapy of herpes simplex virus (HSV), human immunodeficiency virus (HIV), and cytomegalovirus (CMV) infection, varicella-zoster (VZV), hepatitis B and C viruses (Liver Tox, 2021). The nucleoside analogues are similar to the natural nucleotides that ...
Nucleoside analogs: molecular mechanisms signaling cell death
2008年10月27日 · Nucleoside analogs are structurally similar antimetabolites that have a broad range of action and are clinically active in both solid tumors and hematological malignancies.
Advances in the development of nucleoside and nucleotide analogues …
2013年5月31日 · Here, we review new nucleoside analogues and associated compounds that are currently in preclinical or clinical development for the treatment of cancer and viral infections, and that aim to...
Nucleoside analogues: mechanisms of drug resistance and …
2001年7月5日 · Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) and are also...
Nucleoside Analogue - an overview | ScienceDirect Topics
A nucleoside analogue is a pharmacological compound with properties such as cytotoxic, immunosuppressive, and antiviral effects. These compounds, derived from modified purine and pyrimidine nucleobases, are effective in cancer treatment and interact with DNA to induce structural changes.