Review on recent development of quinoline for anticancer activities
2022年11月1日 — As a promising method for anticancer medicines against prostate carcinoma, “4-methyl-2-(3-pyridinyl)quinoline (PQ)” is unique out for its low non-specific cytotoxicity and …
[1,2,4]Triazolo[4,3-a]quinoxaline: synthesis, antiviral, and
2011年8月6日 — Most of the tested compounds exhibited cytotoxicity at concentration 160 μg/ml and compound 8b showed promising antiviral activity. In vitro antimicrobial screening against …
Synthesis, antileishmanial and cytotoxicity activities of fused …
2018年1月31日 — A series of novel triazolo[4,3-a]quinoline, triazino[4,3-a]quinoline, thiadiazepino[5,6-b]quinoline and pyrazolquinoline have been synthesized from the reaction of …
Design, in silico studies and biological evaluation of novel ... - Nature
2024年11月4日 — The results showed that 3e and 3f have potential cytotoxic activities, especially on A549 cells with IC 50 = 2.3 µM and 1.15 µM, respectively. Meanwhile, they recorded a …
Chemical Characteristics, Synthetic Methods, and Biological …
Novel 2,3-disubstituted quinazoline-4(3H)-ones (43) were screened for cytotoxicity and for antiviral activity against influenza A . The 6-Arylbenzimidazo [1,2-c]quinazoline derivatives …
A comprehensive review on the biological interest of quinoline …
2021年2月15日 — Razieh et al. 172 designed some new quinoline (192) derivatives to evaluate their biological activities as aromatase inhibitors and anti-breast cancer agents and cytotoxicity …
1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach ...
Five derivatives demonstrated comparable cytotoxic activity with that of doxorubicin as a reference anticancer drug. Among them, compound 23 showed the most potent activity with IC …
Quinoline tricyclic derivatives. Design, synthesis and evaluation …
2011年12月1日 — As part of an ongoing project to develop new therapeutic agents against Flaviviridae, we here report the cytotoxicity and the antiviral activity of three new classes of …
2021年7月28日 — Tetrahydroquinolines (THQs) are important building blocks in the chemical structure of a wide range of biologically active derivatives such as pyrazolo[3,4-b] quino-lines …
Recent advances in the pharmacological diversification of …
Compounds 33 and 34 had potential cytotoxicity (IC 50 of 15.8 and 17.8 μM, respectively) against the HepG2 cell line as compared with doxorubicin and 5-fluorouracil as positive controls (IC 50 …