CpG oligodeoxynucleotide - Wikipedia
CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide ("C") followed by a guanine triphosphate deoxynucleotide ("G").
TLR9激动剂-CpG ODNs - 知乎 - 知乎专栏
CpG ODNs 是合成的单链DNA短片段，含有特定的非甲基化CpG二核苷酸序列。 CpG ODNs含有部分或全部磷硫酰骨架（phosphorothioated (PS) backbone）。 与细菌基因组DNA的磷酸二酯骨架相对（phosphodiester (PO) backbone）。 三个主要刺激性CpG ODNs的分类，是基于其结构特性与在人外周血单核细胞（PBMC），某些B细胞和 类浆树突细胞（pDC）的活性而划分。 三类CpG ODNs是Class A (Type D), Class B (Type K) 和Class C。 Classes of CpG ODNs. - CpG …
Immunotherapeutic uses of CpG oligodeoxynucleotides - Nature
2004年4月1日 · Human immune cells are stimulated by three structurally distinct classes of CpG oligodeoxynucleotide (ODN). Different types of immune response are triggered by each class of ODN. The innate...
CpG Oligodeoxynucleotide - an overview | ScienceDirect Topics
Cytidine monophosphate guanosine oligodeoxynucleotides (CpG or CpG ODN) are a class of DNA analogs composed of unmethylated cytosine and guanine motifs that mimic bacterial DNA and stimulate the innate immune system by binding to the TLR9 and triggering B cell proliferation, dendritic APC maturation, and Th1-mediated immune activation [86].
High doses of CpG oligodeoxynucleotides stimulate a ... - Nature
2013年5月14日 · Here we show that at high doses, CpG-rich oligodeoxynucleotides promote an opposite, tolerogenic response in mouse plasmacytoid dendritic cells in vivo and in a human in vitro model.
Introduction of sugar-modified nucleotides into CpG-containing ...
2024年5月21日 · In this study, we first established SY-ODN18, an 18-nucleotide phosphorothioate oligodeoxynucleotide with sufficient TLR9-stimulatory activity. We demonstrated that an unmethylated CpG motif...
Nanomaterial-assisted delivery of CpG oligodeoxynucleotides for ...
3 天之前 · CpG oligodeoxynucleotides (CpG) not only act as an adjuvant to promote immune responses, but also induce autophagy. In this review, the enhancement of immunotherapy using nanomaterial-based CpG formulations is systematically elaborated, with a focus on the delivery, protection, synergistic promotion of CpG efficacy by nanomaterials, and ...
CpG Oligodeoxynucleotide - an overview | ScienceDirect Topics
CpG Oligodeoxynucleotides are synthetic DNA molecules used as adjuvants in vaccines to enhance the immune response against infectious pathogens like malaria, hepatitis B virus, pneumococcus, influenza, human immunodeficiency virus, and anthrax. You might find these chapters and articles relevant to this topic.
CpG Oligodeoxynucleotides for Anticancer Monotherapy from …
CpG oligodeoxynucleotides (CpG ODNs), the artificial versions of unmethylated CpG motifs that were originally discovered in bacterial DNA, are demonstrated not only as potent immunoadjuvants but also as anticancer agents by triggering toll-like receptor 9 (TLR9) activation in immune cells.
Characterization of three CpG oligodeoxynucleotide classes with ...
2003年12月19日 · Oligodeoxynucleotides (ODN) with unmethylated deoxycytidyl-deoxyguanosine (CpG) dinucleotides (CpG ODN) mimic the immunostimulatory activity of bacterial DNA and are recognized by the Toll-like receptor 9 (TLR9). CpG ODN of the B-Class stimulate strong B cell and NK cell activation and cytokine production.