Phenolphthalein Laxatives and Risk of Cancer - Oxford Academic
2000年12月6日 · Phenolphthalein was the main component in numerous over-the-counter laxatives, including Ex-Lax and Feen-A-Mint, for most of the 20 th century. The U.S. Food and Drug Administration (FDA) classified phenolphthalein as “safe and effective” in 1975 (1).
Phenolphthalein's Laxative Effects: A Comprehensive Guide
2024年8月1日 · Phenolphthalein is a laxative that works by increasing intestinal movement, facilitating the passage of stool. It is typically used to treat constipation, chronic atonic or spastic constipation, and constipation associated with rectal disorders.
Movement Away From Phenolphthalein in Laxatives - JAMA
2009年5月6日 · Phenolphthalein was formally banned by the Food and Drug Administration as an ingredient in over-the-counter laxatives in 1999 due to concerns of possible carcinogenicity. Products containing phenolphthalein, including ex-lax, were reformulated in 1997 in anticipation of the ban; the active ingredient in ex-lax is now senna.
Phenolphthalein - Wikipedia
Phenolphthalein is described as a stimulant laxative. [16] In addition, it has been found to inhibit human cellular calcium influx via store-operated calcium entry (SOCE, see Calcium release activated channel § Structure ) in vivo .
Phenolphthalein: Uses, Interactions, Mechanism of Action
2007年9月11日 · Phenolphthalein is a drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures. Phenolphthalein was withdrawn in Canada due to concerns with carcinogenicity in 1997. Be among the first to try …
Phenolphthalein - 15th Report on Carcinogens - NCBI Bookshelf
2021年12月21日 · The typical oral dose of phenolphthalein as an over-the-counter laxative was 30 to 200 mg for adults and children aged 12 years or older; the recommended dose was not to exceed 270 mg. Children’s doses were 15 to 30 mg for children aged 2 to 5 years and 30 to 60 mg for children aged 6 to 11 years .
Phenolphthalein | C20H14O4 | CID 4764 - PubChem
Phenolphthalein's production and use as an acid/base indicator, as a laboratory reagent, and its former use as a laxative may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.7X10-13 mm Hg at 25 °C indicates phenolphthalein will exist solely in the particulate phase in ...
Phenolphthalein - an overview | ScienceDirect Topics
Since that time, it had been used as an active ingredient in many over-the-counter (OTC) laxatives drugs. Its initial effects start after 6–8 h and may continue 3–4 days, which suggested its weight loss activity in slimming food until the US Food and Drug Administration suggested withdrawing it from OTC drugs, even though it is being used ...
Phenolphthalein - an overview | ScienceDirect Topics
Phenolphthalein is used in toys as a component of disappearing inks and has been commonly used as a laxative. Phenolphthalein is synthesized by condensation of phthalic anhydride with phenols. It was reported to cause multiple types of cancers on animal models (Dunnick & …
Laxative Oral: Uses, Side Effects, Interactions, Pictures ... - WebMD
Generic Name (S): phenolphthalein-docusate calcm , senna , phenolphthalein-docusate sod , casanthranol-docusate sodium , psyllium. This medication is used to treat constipation. It increases...