2024年11月18日 — INVEGA SUSTENNA doses expressed as 39, 78, 117, 156, and 234 mg of paliperidone palmitate are equal to 25, 50, 75, 100, and 150 mg eq. of paliperidone, respectively.
2024年11月17日 — Following a single intramuscular (IM) dose of INVEGA SUSTENNA, the release of paliperidone starts as early as day 1 and lasts for as long as 126 days. The median apparent half-life of paliperidone following INVEGA SUSTENNA single-dose administration over the dose range of 39 mg - 234 mg ranged from 25 days - 49 days. 1.
To convert IM haloperidol lactate to po haloperidol (Manufacturer rec – does not follow conversion ratio info): Total daily IM dose ≈ total daily po dose. Oral dose can be administered QD
2024年11月18日 — a Conversion factor: 1 mg oral RIS = 39 mg INVEGA SUSTENNA. Note: The conversion does not take into account the potential effects of CYP2D6 inhibitors (i.e. paroxetine, sertraline or fluoxetine) or inducers (i.e. carbamazepine) on active moiety concentrations.
Administer INVEGA TRINZA 1 month after last INVEGA SUSTENNA Dose. Initial dose may be given up to 7 days before or 7 days after monthly time point: 9 months • Re-initiate treatment with INVEGA SUSTENNA® for at least 4 months; then, switch to INVEGA TRINZA®. Administer missed dose ASAP.
In order to make the suggested cross-taper usable, I’ve rounded the doses (of converted TO drug) to whatever the smallest increment of that particular drug is. Any suggestions to improve this tool are welcome and appreciated. 1. Danivas V, Venkatasubramanian G. Current perspectives on chlorpromazine equivalents: Comparing apples and oranges!.