Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF ... with a high incidence of grade 3 hand–foot syndrome/skin reaction (45%). Sorafenib-plus-paclitaxel demonstrated a ...

The formation and reactions of peroxynitrite play a significant role in various diseases. Products of peroxynitrite reactions with macromolecules have been detected in several pathophysiological ...

Cilag’s Rybrevant in combo with Lazcluze for first-line treatment of patients with EGFR-mutated advanced NSCLC: Beerse, Belgium Tuesday, Dec ...

An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

A creatine kinase test is a blood test that measures levels of an enzyme called creatine kinase. This enzyme supports energy production in the body and is particularly important for muscle and ...

Belgium: Janssen-Cilag International NV, a Johnson & Johnson company, has announced that the European Commission (EC) has ...

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

10 was used to exclude the diagnosis of chronic myeloid leukemia blast crisis. Total RNA (1 µg) was obtained from the patient's peripheral blood cells and submitted to reverse transcription polymerase ...

There is evidence that lower doses may be equally effective, especially in patients with less severe edema. [10] If beneficial, neurological improvement can be expected within 48 h with this ...

Anaphylaxis is a medical emergency. If left untreated, it can lead to loss of consciousness, shock, coma, heart or respiratory failure, and death. This severe reaction typically occurs within five to ...